Table 3 Changes in physiological parameters in patients with successful or failed weaning in the HFNC treatment group
Failed n = 40 | Successful n = 318 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
4 h before extubation | 4 h after extubation | 8–12 h later | 20–24 h later | 36–40 h | 4 h before reintubation | 4 h before extubation | 4 h after extubation | 8–12 h later | 20–24 h later | 36–40 h | |
Heart rate, mean (SD) | †89.67(16.07) | †94.62 (17.57) | †94.26 (18.59) | *†99.78 (14.64) | *†115.05 (9.92) | *99.18 (18.88) | 83.01(13.42) | *87.65 (14.48) | *87.93 (14.79) | *85.33 (14.28) | 85.01 (14.56) |
Respiratory rate, mean (SD) | 19.41(4.09) | *†22.83 (4.29) | *22.64 (5.31) | *†24.40 (5.69) | 26.88 (8.09) | *24.47 (4.81) | 19.31(4.29) | *21.21 (4.75) | *21.29 (4.80) | *21.00 (4.58) | *21.02 (4.91) |
Tidal volume, mean (SD) | 527.92(146.70) | – | – | – | – | – | 504.81(126.12) | – | 515.93 (132.49) | – | – |
MBP, mean (SD) | 81.10(13.91) | 80.82 (15.61) | 83.41 (14.24) | 81.46 (14.29) | 81.91 (12.14) | *83.97 (14.58) | 78.34(11.79) | 79.95 (12.62) | 79.32 (14.04) | 79.18 (12.32) | 78.93 (11.57) |
pH, mean (SD) | 7.39(0.07) | 7.37 (0.12) | 7.40 (0.08) | 7.36 (0.10) | 7.42 (0.08) | 7.38 (0.10) | 7.40(0.06) | 7.41 (0.07) | 7.42 (0.06) | *7.43 (0.06) | *7.45 (0.06) |
PaO2, median [Q1, Q3] | 89.25[83.50, 104.62] | 91.50 [74.38,119.00] | *75.50 [64.50,95.00] | *81.00 [72.50,82.75] | 75.50 [68.75,82.25] | *76.75 [66.75,98.50] | 92.50[80.00, 110.00] | *83.00 [71.00,99.00] | *81.00 [71.00,97.00] | *78.00 [69.50,87.00] | *79.00 [68.75,104.50] |
PaCO2, mean (SD) | 39.52(6.60) | 41.78 (7.62) | 39.61 (6.56) | 39.00 (9.94) | 47.50 (4.95) | 40.09 (9.12) | 40.00(6.83) | 39.65 (7.36) | *37.82 (6.83) | *37.72 (8.68) | 37.76 (8.35) |
SpO2, median [Q1, Q3] | 96.50[95.00, 98.29] | *95.12 [93.94,95.88] | *95.38 [93.44,96.43] | *94.25 [93.66,95.62] | 95.00 [94.50,96.25] | *93.27 [91.69,95.29] | 97.00[95.00, 98.50] | *95.00 [93.75,96.59] | *95.00 [93.50,96.50] | *95.00 [93.75,96.50] | *95.25 [93.55,96.94] |
PaO2/FiO2, median [Q1,Q3] | 208.00[170.00, 229.88] | *151.61 [133.75,171.50] | *129.00 [100.83,130.00] | *95.30 [85.99,111.55] | *†75.50 [68.75,82.25] | *98.84 [79.38,147.03] | 201.29[163.20, 238.35] | *137.75 [102.12,175.50] | *126.08 [100.08,171.39] | *126.00 [90.31,171.00] | *133.53 [110.00,171.08] |
ROX Index | †8.61 [7.57,9.45] | 7.38 [5.27,9.49] | 6.95 [5.25,8.75] | 6.54 [4.82,9.33] | 5.32 [3.93, 8.12] | *3.54 (0.43) | 11.63 [9.22,13.51] | *7.29 [6.33,8.62] | *7.97 [7.08,9.01] | 7.51 [6.97,8.06] | 12.24 [9.55,14.94] |
RSBI | 40.35[30.71, 54.80] | – | – | – | – | *49.88 [40.31,55.09] | 39.22[29.87, 50.51] | – | – | – | – |
HR/PaO2 | †0.97(0.22) | 1.05 (0.37) | 1.17 (0.34) | *1.25 (0.27) | 1.64 (0.49) | *1.25 (0.45) | 0.89(0.27) | *1.07 (0.33) | *1.05 (0.32) | *1.13 (0.58) | *1.09 (0.35) |
HR/SpO2 | †0.93(0.16) | †1.00 (0.19) | 0.99 (0.19) | *†1.06 (0.16) | *†1.22 (0.10) | *1.06 (0.20) | 0.86(0.14) | *0.92 (0.15) | *0.93 (0.16) | *0.90 (0.15) | *0.89 (0.15) |