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Table 3 Changes in physiological parameters in patients with successful or failed weaning in the HFNC treatment group

From: Effects of high-flow oxygen therapy on patients with hypoxemia after extubation and predictors of reintubation: a retrospective study based on the MIMIC-IV database

  Failed n = 40 Successful n = 318
  4 h before extubation 4 h after extubation 8–12 h later 20–24 h later 36–40 h 4 h before reintubation 4 h before extubation 4 h after extubation 8–12 h later 20–24 h later 36–40 h
Heart rate, mean (SD) †89.67(16.07) †94.62 (17.57) †94.26 (18.59) *†99.78 (14.64) *†115.05 (9.92) *99.18 (18.88) 83.01(13.42) *87.65 (14.48) *87.93 (14.79) *85.33 (14.28) 85.01 (14.56)
Respiratory rate, mean (SD) 19.41(4.09) *†22.83 (4.29) *22.64 (5.31) *†24.40 (5.69) 26.88 (8.09) *24.47 (4.81) 19.31(4.29) *21.21 (4.75) *21.29 (4.80) *21.00 (4.58) *21.02 (4.91)
Tidal volume, mean (SD) 527.92(146.70) 504.81(126.12) 515.93 (132.49)
MBP, mean (SD) 81.10(13.91) 80.82 (15.61) 83.41 (14.24) 81.46 (14.29) 81.91 (12.14) *83.97 (14.58) 78.34(11.79) 79.95 (12.62) 79.32 (14.04) 79.18 (12.32) 78.93 (11.57)
pH, mean (SD) 7.39(0.07) 7.37 (0.12) 7.40 (0.08) 7.36 (0.10) 7.42 (0.08) 7.38 (0.10) 7.40(0.06) 7.41 (0.07) 7.42 (0.06) *7.43 (0.06) *7.45 (0.06)
PaO2, median [Q1, Q3] 89.25[83.50, 104.62] 91.50 [74.38,119.00] *75.50 [64.50,95.00] *81.00 [72.50,82.75] 75.50 [68.75,82.25] *76.75 [66.75,98.50] 92.50[80.00, 110.00] *83.00 [71.00,99.00] *81.00 [71.00,97.00] *78.00 [69.50,87.00] *79.00 [68.75,104.50]
PaCO2, mean (SD) 39.52(6.60) 41.78 (7.62) 39.61 (6.56) 39.00 (9.94) 47.50 (4.95) 40.09 (9.12) 40.00(6.83) 39.65 (7.36) *37.82 (6.83) *37.72 (8.68) 37.76 (8.35)
SpO2, median [Q1, Q3] 96.50[95.00, 98.29] *95.12 [93.94,95.88] *95.38 [93.44,96.43] *94.25 [93.66,95.62] 95.00 [94.50,96.25] *93.27 [91.69,95.29] 97.00[95.00, 98.50] *95.00 [93.75,96.59] *95.00 [93.50,96.50] *95.00 [93.75,96.50] *95.25 [93.55,96.94]
PaO2/FiO2, median [Q1,Q3] 208.00[170.00, 229.88] *151.61 [133.75,171.50] *129.00 [100.83,130.00] *95.30 [85.99,111.55] *†75.50 [68.75,82.25] *98.84 [79.38,147.03] 201.29[163.20, 238.35] *137.75 [102.12,175.50] *126.08 [100.08,171.39] *126.00 [90.31,171.00] *133.53 [110.00,171.08]
ROX Index †8.61 [7.57,9.45] 7.38 [5.27,9.49] 6.95 [5.25,8.75] 6.54 [4.82,9.33] 5.32 [3.93, 8.12] *3.54 (0.43) 11.63 [9.22,13.51] *7.29 [6.33,8.62] *7.97 [7.08,9.01] 7.51 [6.97,8.06] 12.24 [9.55,14.94]
RSBI 40.35[30.71, 54.80] *49.88 [40.31,55.09] 39.22[29.87, 50.51]
HR/PaO2 †0.97(0.22) 1.05 (0.37) 1.17 (0.34) *1.25 (0.27) 1.64 (0.49) *1.25 (0.45) 0.89(0.27) *1.07 (0.33) *1.05 (0.32) *1.13 (0.58) *1.09 (0.35)
HR/SpO2 †0.93(0.16) †1.00 (0.19) 0.99 (0.19) *†1.06 (0.16) *†1.22 (0.10) *1.06 (0.20) 0.86(0.14) *0.92 (0.15) *0.93 (0.16) *0.90 (0.15) *0.89 (0.15)
  1. P < 0.05 versus value of patients with successful weaning, *P < 0.05 vs value at baseline