Table 4 Factors that may mitigate COVID-19 in cystic fibrosis
From: Systematic review: cystic fibrosis in the SARS-CoV-2/COVID-19 pandemic
Category | Mitigating factor |
|---|---|
Preventative measures | Social distancing/self-isolation |
| Â | Masking |
| Â | Frequent hand-hygiene |
Physiological | Lower median age |
| Â | ACE and ACE2 expression |
| Â | Localized respiratory tract reduction of IL-6 |
| Â | Altered interaction between SARS-CoV 3CLpro and CFTR |
| Â | Thick secretions in respiratory tract |
| Â | Existing microbiota |
| Â | Elevated autophagy induction |
Therapeutic/Interventional | Neutrophil elastase inhibitors |
| Â | Dornase alfa |
| Â | Azithromycin |