Skip to main content

Table 4 Factors that may mitigate COVID-19 in cystic fibrosis

From: Systematic review: cystic fibrosis in the SARS-CoV-2/COVID-19 pandemic

Category Mitigating factor
Preventative measures Social distancing/self-isolation
  Masking
  Frequent hand-hygiene
Physiological Lower median age
  ACE and ACE2 expression
  Localized respiratory tract reduction of IL-6
  Altered interaction between SARS-CoV 3CLpro and CFTR
  Thick secretions in respiratory tract
  Existing microbiota
  Elevated autophagy induction
Therapeutic/Interventional Neutrophil elastase inhibitors
  Dornase alfa
  Azithromycin
  1. ACE Angiotensin-converting enzyme, ACE2 Angiotensin-converting enzyme 2, IL-6 Interleukin-6, 3CLpro 3-chymotrypsin-like cysteine proteinase, CFTR CF transmembrane conductance regulator