From: Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity
 | Asbestosis | Silicosis | Controls | P value* |
---|---|---|---|---|
Subjects | 30 | 23 | 25 | – |
Age, years | 71.3 ± 8.7 | 52.9 ± 12.0 | 46.8 ± 5.4 | 0.000 |
Female/male, n | 17/13 | 14/9 | 7/18 | 0.040 |
Smoker/non-smoker,n | 12/18 | 4/19 | 13/12 | 0.043 |
PaO2, mmHg | 77.63 ± 11.73 | 79.94 ± 14.12 | 87.92 ± 2.69 | 0.041 |
FVC, %pred | 61.18 ± 23.30 | 88.87 ± 22.36 | 89.16 ± 2. 54 | 0.000 |
FEV1, %pred | 59.74 ± 24.15 | 70.47 ± 27.59 | 89.80 ± 8.45 | 0.000 |
FEV1/FVC, % | 75.81 ± 10.90 | 67.07 ± 16.55 | 87.24 ± 2.82 | 0.000 |
TLC, %pred | 74.07 ± 20.87 | 83.02 ± 31.25 | 90.52 ± 3.02 | 0.290 |
DLCO, %pred | 55.86 ± 25.93 | 76.47 ± 17.96 | 85.84 ± 3.24 | 0.000 |