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Table 2 Initial variables of the whole cohort (fever > 120 h)

From: Prediction model for prolonged fever in patients with Mycoplasma pneumoniae pneumonia: a retrospective study of 716 pediatric patients

  Training cohort (n = 501) Test cohort (n = 215)
Fever ≥ 120 h Fever < 120 h p-value Fever ≥ 120 h Fever < 120 h p-value
Number of patients (n, %) 65 (13.0) 436 (87.0)   31 (14.4) 184 (85.6)  
Age, mean (years) 6.1 ± 2.5 5.7 ± 3.1 0.217 5.7 ± 3.0 5.3 ± 3.1 0.496
Sex ratio (female: male) 1.8 0.9 0.011 2.4 1.0 0.030
Duration of fever (days)
 At admission 4.2 ± 1.4 5.1 ± 2.1 < 0.001 4.4 ± 1.5 4.9 ± 2.0 0.130
 After admission 7.6 ± 3.6 1.7 ± 1.2 < 0.001 7.8 ± 4.1 1.6 ± 1.2 < 0.001
 Total 11.0 ± 3.8 7.0 ± 2.3 < 0.001 11.3 ± 4.6 6.6 ± 2.3 < 0.001
 Total hospital days (days) 11.8 ± 3.7 6.0 ± 2.0 < 0.001 12.0 ± 4.2 5.7 ± 1.7 < 0.001
Initial inflammatory markers
 WBC × 103/µL 7.5 ± 3.4 9.4 ± 6.8 0.030 7.0 ± 3.0 8.6 ± 3.7 0.031
  Neutrophils (%) 71.0 ± 9.6 64.0 ± 13.7 < 0.001 66.8 ± 12.1 62.0 ± 13.0 0.058
  Absolute neutrophil count × 103/µL 5.5 ± 3.0 6.2 ± 5.2 0.290 4.5 ± 1.5 5.5 ± 3.1 0.011
  Lymphocytes (%) 20.4 ± 7.2 25.8 ± 11.8 < 0.001 23.9 ± 10.0 27.5 ± 11.4 0.106
  Absolute lymphocyte count × 103/µL 1.0 ± 0.4 1.3 ± 1.0 < 0.001 1.0 ± 0.5 1.3 ± 0.6 0.020
 Platelet × 103/µL 208.2 ± 50.0 298.2 ± 100.9 < 0.001 219.3 ± 72.9 286.3 ± 89.9 < 0.001
 ESR (mm/hr) 34.2 ± 15.8 36.2 ± 18.5 0.392 32.8 ± 15.6 36.5 ± 18.9 0.303
 CRP (mg/L) 68.4 ± 67.3 29.6 ± 33.9 < 0.001 57.9 ± 53.1 27.7 ± 25.9 0.004
 Procalcitonin (ng/mL) 0.7 ± 1.4 0.5 ± 1.8 0.512 1.3 ± 2.3 0.5 ± 1.8 0.261
Other laboratory data
 LDH (IU/L) 379.0 ± 147.6 334.4 ± 85.5 0.020 407.3 ± 139.9 328.9 ± 71.5 0.005
 AST (IU/L) 43.1 ± 22.2 38.7 ± 37.3 0.346 46.2 ± 23.1 35.1 ± 11.2 0.013
 ALT (IU/L) 17.4 ± 11.6 25.8 ± 71.6 0.351 23.2 ± 16.6 16.2 ± 10.9 0.030
Concurrent respiratory virus (n, %) 13 (24.1) 125 (33.7) 0.158 7 (39.2) 43 (27.4) 0.856
Oxygen requirement (n, %) 4 (6.2) 9 (2.1) 0.075 2 (6.5) 3 (1.6) 0.152
Radiologic grouping (n, %)
 Group 1 3 (4.6) 112 (25.7) < 0.001 3 (9.7) 54 (29.3) < 0.001
 Group 2 18 (27.7) 194 (44.5)   6 (19.4) 86 (46.7)  
 Group 3 33 (50.8) 126 (28.9)   17 (54.8) 42 (22.8)  
 Group 4 11 (16.9) 4 (0.9)   5 (16.1) 2 (1.1)  
Pleural effusion (n, %) 19 (29.2) 34 (7.8) < 0.001 9 (29.0) 16 (8.7) 0.003
Radiologic aggravation on the 3rd or 4th hospital day (n, %) 59 (90.8) 108 (24.8) < 0.001 25 (80.6) 34 (18.5) < 0.001
Fever profiles
 Highest temperature (°C) 39.6 ± 0.6 38.7 ± 0.7 < 0.001 39.4 ± 0.6 38.7 ± 0.7 < 0.001
 Lowest temperature (°C) 37.0 ± 0.3 36.6 ± 0.3 < 0.001 36.9 ± 0.3 36.6 ± 0.3 < 0.001
 Frequency of fever > 39 °C within 48 h (n) 3.3 ± 2.8 0.7 ± 1.4 < 0.001 2.9 ± 1.7 0.6 ± 1.2 < 0.001
 Frequency of fever > 40 °C within 48 h (n) 0.5 ± 1.0 0.1 ± 0.3 < 0.001 0.3 ± 0.6 0.0 ± 0.2 0.070
 Frequency of peak fever within 24 h (n) 4.7 ± 1.2 2.9 ± 1.4 < 0.001 4.6 ± 1.0 2.8 ± 1.3 < 0.001
 Frequency of peak fever within 48 h (n) 8.7 ± 1.7 4.6 ± 2.7 < 0.001 8.6 ± 1.7 4.5 ± 2.6 < 0.001
12 sequential body temperatures
 Initial (°C) 38.6 ± 0.9 37.9 ± 0.9 < 0.001 38.2 ± 0.9 37.9 ± 0.9 0.100
 After 4 h (°C) 38.1 ± 0.9 37.6 ± 0.8 < 0.001 38.0 ± 0.9 37.6 ± 0.7 0.008
 After 8 h (°C) 37.9 ± 0.8 37.4 ± 0.9 < 0.001 38.0 ± 1.1 37.5 ± 0.8 0.016
 After 12 h (°C) 37.9 ± 0.9 37.4 ± 0.9 < 0.001 38.0 ± 1.0 37.4 ± 0.8 < 0.001
 After 16 h (°C) 38.0 ± 1.0 37.4 ± 0.8 < 0.001 38.0 ± 0.9 37.3 ± 0.8 < 0.001
 After 20 h (°C) 38.2 ± 0.9 37.4 ± 0.7 < 0.001 38.2 ± 0.6 37.4 ± 0.8 < 0.001
 After 24 h (°C) 38.0 ± 0.6 37.4 ± 0.7 < 0.001 38.2 ± 0.6 37.5 ± 0.7 < 0.001
 After 28 h (°C) 38.3 ± 1.0 37.5 ± 0.8 < 0.001 37.9 ± 0.7 37.4 ± 0.7 < 0.001
 After 32 h (°C) 37.7 ± 1.0 37.0 ± 2.4 0.040 37.9 ± 1.0 37.2 ± 0.7 0.001
 After 36 h (°C) 37.9 ± 0.9 37.1 ± 0.7 < 0.001 37.6 ± 0.7 37.1 ± 0.8 0.001
 After 40 h (°C) 38.1 ± 0.9 37.1 ± 0.7 < 0.001 37.9 ± 0.9 37.0 ± 0.7 < 0.001
 After 44 h (°C) 38.1 ± 0.8 37.1 ± 0.7 < 0.001 37.8 ± 0.8 37.1 ± 0.7 < 0.001
  1. Continuous variables are presented as mean ± standard deviation
  2. Categorical variables are presented as frequencies (%)
  3. ESR Erythrocyte sedimentation rate, CRP C-reactive protein, LDH Lactate dehydrogenase, AST Aspartate aminotransferase, ALT Alanine aminotransferase, WBC White blood cell
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