Variable | OSI (n = 60) | AFA (n = 64) | p value |
---|---|---|---|
Age (years) | 64.24 ± 12.33 | 64.13 ± 13.72 | 0.72a |
Sex (male/female), No.% | 25/35 | 28/36 | 0.82b |
BMI (kg/m2) | 23.74 ± 2.31 | 24.15 ± 2.46 | 0.26a |
Smoking status, No.% | Â | Â | 0.81c |
 Never a smoker | 11 | 13 |  |
 Former smokers | 32 | 30 |  |
 Current smokers | 17 | 21 |  |
Time from diagnosis of NSCLC (months), No.% | Â | Â | 0.78c |
 < 6 | 15 | 17 |  |
 6–12 | 35 | 33 |  |
 > 12 | 10 | 14 |  |
Largest size of brain metastasis, No.% | Â | Â | 0.31c |
 ≤ 10 mm | 22 | 18 |  |
 > 10 mm | 38 | 46 |  |
Number of brain metastases, No.% | Â | Â | 0.47c |
 ≤ 3 | 32 | 30 |  |
 > 3 | 28 | 34 |  |
Previous EGFR-TKI therapy, No.% | Â | Â | 0.41c |
 Erlotinib | 23 | 20 |  |
 Gefitinib | 16 | 18 |  |
 Afatinib | 21 | 26 |  |
Type of EGFR mutation, No.% | Â | Â | 0.91c |
 T790M and Exon 19 deletion | 35 | 38 |  |
 T790M and Exon 21 L858R | 25 | 26 |  |
Distant metastasis except for CNS, No.% | Â | Â | 0.54c |
 Gastrointestinal | 22 | 18 |  |
 Pancreas | 11 | 14 |  |
 Liver | 12 | 16 |  |
 Pancreas | 12 | 14 |  |
 Other | 3 | 2 |  |
ECOG performance status, No.% | Â | Â | 0.97c |
 0 | 9 | 12 |  |
 1 | 27 | 25 |  |
 2 | 24 | 27 |  |