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Fig. 2 | BMC Pulmonary Medicine

Fig. 2

From: ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial–mesenchymal transition

Fig. 2

Ralationship between different ID1 expression and EMT related protein. a Gene silencing using siRNA targeting ID1 and b overexpression of ID1 by cloning the gene into the pcDNA3.0 vector. c and d RT-PCR and western blot were used to confirmed the effects of ID1 silencing and overexpression on osimertinib-resistant cells. Results showed that the expression of ID1 was closely related to E-cadherin and vimentin. Up- and down-regulation of ID1 expression in H1975/OR cells inhibited and promoted the expression of E-cadherin, respectively. Each point represents the mean ± SD from 3 independent experiments.*P < 0.05 versus H1975/OR

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BMC Pulmonary Medicine

ISSN: 1471-2466

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