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Fig. 6 | BMC Pulmonary Medicine

Fig. 6

From: ID1 mediates resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer through epithelial–mesenchymal transition

Fig. 6

Flow cytometry analysis of the cell cycle of osimertinib-sensitive and resistant cells. Compared with H1975/OR cells, cells were arrested in the G1/G0 phase in H1975 cells (56.15 ± 0.77% versus 68.29 ± 1.24%). By down-regulating ID1, this result was reversed in H1975/OR + si-ID1 cells (56.15 ± 0.77% versus 63.05 ± 0.82%), while in ID1 overexpressed H1975/OR + pcDNA3.0-ID1 cells, the effect on cell cycle was further aggravated (56.15 ± 0.77% versus 49.96 ± 0.44%). Representative results are shown from at least 3 independent experiments.*P < 0.05 versus H1975/OR

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BMC Pulmonary Medicine

ISSN: 1471-2466

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