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Fig. 2 | BMC Pulmonary Medicine

Fig. 2

From: Down-regulation of SNHG16 alleviates the acute lung injury in sepsis rats through miR-128-3p/HMGB3 axis

Fig. 2

SNHG16 knockdown attenuated sepsis-induced ALI. sh-SNHG16 was used for establishing a SNHG16-knockdodwn rats, which were then subjected to CLP to induce a sepsis model. a, b qRT-PCR was employed to examine the expression of SNHG16 and miR-128-3p in the lung tissue of rats. c Western blot was employed to examine the expression of HMGB3 in the lung tissue of rats. d HE staining was performed to observe the lung pathological changes of rat lung tissues. e, f IHC was implemented to monitor the Caspase3 (e) and MPO (f) expression in the rat lung tissue; G: The pulmonary edema was determined with the W/D method; h, j The arterial blood of rats was adopted for blood gas analysis to verify the changes in lung function. **P < 0.01; ***P < 0.001 (vs. Sham group); #P < 0.05; ##P < 0.01; ###P < 0.001 (vs. Sham group). N = 5. All experiments were repeated for three times

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