Fig. 3

SNHG16 knockdown repressed sepsis-mediated inflammation. sh-SNHG16 was used for establishing a SNHG16-knockdodwn rats, which were then subjected to CLP to induce a sepsis model. a–c ELISA was employed to test the levels of the pro-inflammatory factors (including TNF-α, IL-1β, and IL-6); d WB was implemented to monitor the levels of the pro-inflammatory proteins NF-κB, MAPK-P38, iNOS and COX2 in the lung tissues. ***P < 0.001 (vs. Sham group); #P < 0.05; ^##P < 0.01; ^###P < 0.001 (vs. CLP + sh-NC group). N = 5. All experiments were repeated for three times