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Fig. 2 | BMC Pulmonary Medicine

Fig. 2

From: EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation

Fig. 2

Activation status of STAT proteins in EML4-ALK-positive lung cancer. a STAT6 and JAK2 were constitutively phosphorylated in H2228 cells. EML4-ALK knockdown downregulated phosphorylation of JAK2 and STAT6 in H2228 cells. b colocalization of ALK, p-STAT6, and p-JAK2 staining in primary tumor tissue. c Representative images of ALK,p-JAK2 and p-STAT6 expression by immunohistochemical analysis in the primary tumors and metastatic tumors of EML4-ALK-positive lung cancer patients

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