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Table 1 Characteristics of patients with EML4-ALK-positive NSCLC and the associated JAK2 and STAT6 protein expression

From: EML4-ALK-mediated activation of the JAK2-STAT pathway is critical for non-small cell lung cancer transformation

Case number

Smoking status

Histology (H&E)

pTNM

ALK/P-JAK2/P-STAT6 IHC at primary sites

ALK/P-JAK2/P-STAT6-IHC at metastatic sites

1-147

Non

AD

T2aN2M0

 + / + / + 

–/–/–

2-159

Non

Mixed-AD

T1N2M0

 + / ± 

 + / ± 

3-161

Non

Mixed-AD

T1N2M0

 + / + / + 

–/–/–

4-170

Non

Ad + SCC

T2bN2M0

 + / ± 

–/–/–

5-177

Non

Mixed -AD

T2aN1M0

 + / + / + 

 + / ± 

6-184

Yes

Mixed -AD

T2aN1M1

 + / + / + 

 + / ± 

7-98

Non

Mucinous BAC

T2aN0M0

 + / + / + 

/

  1. AD adenocarcinoma, SCC squamous carcinoma, BAC bronchioloalveolar carcinoma, + positive, − negative