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Table 3 Univariable and multivariable analysis of risk factor of acute exacerbation of interstitial pneumonia

From: Serum S100 calcium-binding protein A4 as a novel predictive marker of acute exacerbation of interstitial pneumonia after surgery for lung cancer

 

Univariable analysis

Multivariable analysis

OR (95%CI)

P value

OR (95%CI)

P value

S100A4 high (≥ 17.13 ng/ml)

21.39 (4.64–98.64)

 < 0.001

42.28 (3.98–449.29)

0.002

Male

N/A*

0.010

N/A*

0.033

Collagen disease

0.82 (0.10–6.79)

0.852

0.01 (0.01–4.57)

0.141

%VC (≤ 80%)

4.21 (1.46–12.20)

0.008

10.20 (1.26–82.26)

0.029

DLCO (≤ 40%)

2.62 (0.83–8.31)

0.102

5.61 (0.30–103.97)

0.246

Preoperative steroid use

2.17 (0.43–11.08)

0.350

6.29 (0.22–180.26)

0.283

Radiologic UIP pattern

3.37 (1.13–10.02)

0.029

5.13 (0.624–42.22)

0.128

KL-6 (≥ 1000)

4.81 (1.43–16.26)

0.011

1.48 (0.09–24.59)

0.786

Operative time (continuous value)

1.01 (1.00–1.02)

0.048

1.03 (1.01–1.04)

0.001

Anatomical resection

1.27 (0.39–4.14)

0.694

3.21 (0.33–31.37)

0.315

  1. OR odds ratio, CI confidence interval, S100A4 S100 calcium-binding protein A4, N/A not available, VC vital capacity, DLCO diffusing capacity for carbon monoxide, UIP usual interstitial pneumonia, KL-6 krebs von den lungen-6
  2. *OR could not be calculated because none of female patients experienced AE of IP