|
Etiologies of ARDS
|
Pneumonia
|
Aspiration
|
Non-pulmonary sepsis
|
p-valuesa
|
|---|
|
All pneumonia
|
Bacteria
|
Influenza
|
Pneumocystis jiroveci
|
|---|
|
Respiratory parameters
|
|
PaO2/FiO2 ratios
|
143 (99–194)
|
142 (94–197)
|
128 (73–144)
|
143 (116–266)
|
166 (120–183)
|
122 (87–194)
|
0.66
|
|
Ventilatory ratios
|
1.5 (1.2–2.0)
|
1.6 (1.1–2.1)
|
1.8 (1.7–2.2)
|
1.4 (1.2–1.8)
|
1.8 (1.4–2.3)
|
1.7 (1.3–2.2)
|
0.20
|
|
Static respiratory compliance, mL/cm H2O
|
32 (25–41)
|
30 (24–41)
|
34 (32–46)
|
33 (25–42)
|
30 (24–38)
|
29 (25–44)
|
0.92
|
|
Non-pulmonary organ dysfunction
|
|
Vasopressor users, %
|
48 (39–57)
|
56 (45–67)
|
33 (7–70)
|
27 (8–55)
|
63 (24–91)
|
73 (54–88)
|
0.03
|
|
Non-pulmonary SOFA score
|
6 (3–8)
|
6 (3–9)
|
4 (2–7)
|
5 (2–8)
|
8 (5–11)
|
9 (6–12)
|
< 0.001
|
|
Biomarkers in inflammation and coagulation
|
|
C-reactive protein, mg/dL
|
15.9 (8–23.1)
|
16.5 (9.7–25.7)
|
15.4 (6.6–22.1)
|
15.5 (8.5–18.8)
|
16 (1.9–19)
|
10.3 (2.8–16.5)
|
0.16
|
|
D-dimer, mg/L
|
4.2 (2.1–7.8)
|
4.9 (2.4–8.9)
|
5.7 (3.3–9.5)
|
1.9 (1.7–6.2)
|
17.3 (1–31.3)
|
9.7 (3.6–14.8)
|
0.07
|
|
Lactic acid, mmol/L
|
2.2 (1.5–3.5)
|
2.3 (1.5–4.2)
|
1.9 (1.5–2.1)
|
1.9 (1.1–2.4)
|
3.1 (2.5–13.5)
|
5.6 (2.6–8.4)
|
< 0.001
|
|
Outcome
|
|
30-day mortality, %
|
43 (34–52)
|
43 (32–54)
|
22 (3–60)
|
53 (27–79)
|
63 (24–91)
|
67 (47–83)
|
0.04
|
- Data were presented as median with interquartile range or proportions with 95% confidence intervals
- aBetween-group comparison among pneumonia, aspiration and non-pulmonary sepsis
