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Table 4 Decision tree chance node sensitivity analysis

From: The optimal timing of FDG-PET/CT in non-small cell lung cancer diagnosis and staging in an Australian centre

Chance node

CT-guided Lung Biopsy Sensitivity

Radial EBUS sensitivity

Linear EBUS sensitivity

Radiologically guided percutaneous biopsy sensitivity

HAL threshold for mediasitinal staging

“CT-First” Probability of requiring more than one diagnostic test

“FDG-PET/CT First” Probability of requiring more than one diagnostic test

Difference in probabilities

% Change from base case

Base case

 

93%

73%

89%

93%

10%

0.192

0.121

0.071

N/A

CT-guided Lung Biopsy Sensitivity

 

90%

    

0.205

0.131

0.074

3.4%

 

96%

    

0.180

0.104

0.076

7.2%

Radial EBUS Sensitivity

  

69%

   

0.204

0.129

0.075

5.3%

  

80%

   

0.229

0.101

0.128

79.8%

Linear EBUS Sensitivity

   

Mean HAL score (25.8%)

  

0.330

0.209

0.121

69.6%

   

46%

  

0.286

0.181

0.105

47.3%

   

97%

  

0.175

0.110

0.065

− 8.8%

Image-Guided Percutaneous Biopsy Sensitivity

    

90%

 

0.193

0.123

0.070

− 2.6%

    

96%

 

0.192

0.119

0.073

2.6%

HAL threshold for systematic pre-treatment mediastinal staging

     

17.5%

0.140

0.101

0.039

− 45.5%

     

25%

0.128

0.101

0.027

− 62.0%