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Table 1 Clinical characteristics on admission to the weaning center— comparison of patients with weaning success and weaning failure

From: Mechanical power normalized to lung-thorax compliance predicts prolonged ventilation weaning failure: a prospective study

Clinical characteristics All patients
(n = 130)
Weaning success
(n = 86)
Weaning failure
(n = 44)
P valuea
Age (years) 69 (60–76) 68 (59–76) 70 (63–75) 0.609c
Gender (male) 82 (63.1) 59 (68.8) 23 (52.3) 0.069d
Body mass index (kg/m2) 27.9 (± 6.9) 27.3 (± 6.6) 29.1 (± 7.4) 0.369c
 Obesity (BMI ≥ 30 kg/m2) 40 (30.8) 24 (27.9) 16 (36.4) 0.325d
Smoking history 48 (36.9) 21 (24.5) 27 (61.4)  < 0.001d
APACHE-II (points) 15.9 (± 5.3) 15.8 (± 5.3) 15.9 (± 5.4) 0.905b
Albumin (g/dL) 2.2 (± 0.5) 2.2 (± 0.6) 2.2 (± 0.5) 0.338c
Ventilator days on admission 25 (16–34) 27 (17–35) 23 (16–30) 0.123c
Time from Intubation to tracheostomy (days) 12 (7–18) 13 (7–19) 10 (6–15) 0.057c
ECLA 14 (10.8) 13 (15.1) 1 (2.3) 0.026d
Reason for mechanical ventilation
Pneumonia 51 (39.2) 31 (36.0) 20 (45.5) 0.300d
 SARS-CoV-2 infection 4 (3.1) 4 (4.7) 0 (0.0)
Surgery 32 (24.6) 25 (29.1) 7 (15.9) 0.101d
Cardiopulmonary resuscitation 10 (7.7) 8 (9.3) 2 (4.5) 0.337d
Acute exacerbation of COPD 10 (7.7) 2 (2.3) 8 (18.2) 0.001d
Acute heart failure 6 (4.6) 5 (5.8) 1 (2.3) 0.663e
Sepsis (including septic shock) 7 (5.4) 5 (5.8) 2 (4.5) 1.000e
Other 17 (13.1) 10 (11.6) 7 (15.9) 0.495d
Comorbidities
Charlson comorbidity index (points) 5.5 (± 2.3) 5.4 (± 2.4) 5.6 (± 2.1) 0.611c
Renal insufficiency 46 (35.4) 36 (41.9) 10 (22.7) 0.032d
 Hemodialysis 24 (18.5) 21 (24.4) 3 (6.8) 0.289d
Diabetes mellitus 35 (26.9) 20 (23.3) 15 (34.1) 0.189d
Coronary artery disease 33 (25.4) 23 (26.7) 10 (22.7) 0.620d
COPD 30 (23.1) 5 (5.8) 25 (56.8)  < 0.001d
Chronic heart failure 17 (13.1) 14 (16.3) 3 (6.8) 0.132d
Malignancy 10 (7.7) 7 (8.1) 3 (6.8) 0.790d
Hepatopathy 7 (5.4) 5 (5.8) 2 (4.5) 1.000e
Interstitial lung disease 8 (6.2) 6 (7.0) 2 (4.5) 0.716e
  1. Continuous variables are presented as arithmetic means (± standard deviation) or median (– interquartile range [IQR]); categorical variables are presented as number (%)
  2. BMI body mass index, APACHE-II Acute Physiology and Chronic Health Evaluation II score, ECLA extracorporeal lung assistance (in acute respiratory failure), SARS-CoV-2 severe acute respiratory syndrome-Coronavirus 2, COPD chronic obstructive pulmonary disease
  3. aP value for differences between patients with weaning success and weaning failure
  4. bStudent’s t-test
  5. cMann–Whitney U-test
  6. dChi-squared test
  7. eFisher’s exact test