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Table 3 Cross-validated performance of variables analyzed to predict weaning outcome—mean values derived from the test sets

From: Mechanical power normalized to lung-thorax compliance predicts prolonged ventilation weaning failure: a prospective study

Variables Failure of prolonged weaning
Sens Spec PPV NPV Accuracy PLR NLR DOR F1 MCC
Post-SBT
PaCO2 on MV 78 (56–93) 73 (58–85) 61 (47–73) 87 (75–94) 75 (63–85) 3.1 (1.7–5.5) 0.3 (0.7–0.1) 11.1 0.68 0.50
VR 73 (50–89) 71 (55–84) 56 (43–69) 84 (72–91) 72 (59–82) 2.6 (1.5–4.4) 0.4 (0.8–0.2) 7.2 0.63 0.42
LTCdyn 68 (46–85) 71 (55–84) 54 (40–67) 82 (71–89) 70 (57–81) 2.4 (1.4–4.1) 0.4 (0.8–0.3) 7.7 0.60 0.38
MP 66 (44–84) 64 (48–78) 48 (36–53) 79 (67–87) 65 (52–76) 1.8 (1.1–3.0) 0.5 (1.0–0.3) 4.5 0.55 0.28
PBW-MP 68 (45–86) 68 (52–81) 53 (40–66) 81 (69–89) 68 (55–79) 2.3 (1.3–4.1) 0.5 (0.9–0.3) 5.6 0.59 0.35
LTCdyn-MP 73 (51–88) 67 (54–80) 53 (41–65) 83 (71–90) 69 (56–80) 2.3 (1.4–3.9) 0.4 (0.8–0.2) 7.3 0.61 0.38
PIrs1.0 74 (52–89) 73 (58–86) 58 (45–71) 85 (73–92) 73 (61–84) 2.9 (1.6–4.1) 0.4 (0.7–0.2) 11.3 0.65 0.45
PIrs2.0 78 (56–92) 76 (61–88) 63 (49–75) 87 (75–94) 77 (65–86) 3.4 (1.9–6.2) 0.3 (0.6–0.1) 15.3 0.70 0.52
Pre-weaning completion
PaCO2 on MV 77 (55–92) 76 (60–87) 62 (48–74) 87 (75–93) 76 (64–86) 3.2 (1.8–5.8) 0.3 (0.7–0.1) 11.6 0.69 0.51
VR 70 (47–88) 66 (50–79) 52 (39–64) 81 (69–90) 67 (55–78) 2.1 (1.3–3.5) 0.5 (0.9–0.2) 4.8 0.59 0.35
LTCdyn 69 (44–88) 76 (61–87) 56 (41–69) 86 (75–92) 74 (62–84) 3.2 (1.7–6.3) 0.4 (0.8–0.2) 9.4 0.61 0.43
MP 70 (48–87) 60 (44–74) 48 (37–59) 80 (67–89) 63 (51–75) 1.8 (1.1–2.9) 0.5 (1.0–0.2) 3.8 0.57 0.29
PBW-MP 68 (45–86) 67 (51–80) 51 (39–64) 81 (68–89) 67 (55–78) 2.1 (1.2–3.5) 0.5 (0.9–0.3) 4.6 0.58 0.33
LTCdyn-MP 74 (53–88) 77 (62–89) 62 (47–75) 86 (75–92) 76 (64–86) 3.3 (1.8–6.2) 0.3 (0.7–0.2) 18.5 0.67 0.49
PIrs1.0 82 (61–94) 81 (66–91) 68 (53–81) 90 (78–95) 81 (70–90) 4.4 (2.3–8.5) 0.2 (0.6–0.1) 42.9 0.74 0.61
PIrs2.0 88 (67–97) 83 (69–93) 73 (58–84) 93 (81–97) 85 (74–92) 5.9 (2.8–13) 0.2 (0.5–0.1) 52.8 0.79 0.68
  1. Assessment of mean sensitivity and specificity, positive and negative predictive value, positive and negative likelihood ratio, diagnostic odds ratio, F1 score, and Matthews correlation coefficient (with 95% confidence intervals)
  2. SBT spontaneous breathing trial, Sens sensitivity, Spec specificity, PPV positive predictive value, NPV negative predictive value, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic odds ratio, F1 F1 score, MCC Matthews correlation coefficient, MV mechanical ventilation, VR ventilatory ratio, LTCdyn dynamic lung-thorax compliance, MP mechanical power, PBW-MP mechanical power normalized to predicted body weight, LTCdyn-MP mechanical power normalized to dynamic lung-thorax compliance, PIrs power index of the respiratory system