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Fig. 5 | BMC Pulmonary Medicine

Fig. 5

From: Dual targeting of MEK and PI3K effectively controls the proliferation of human EGFR-TKI resistant non-small cell lung carcinoma cell lines with different genetic backgrounds

Fig. 5

Effect of MEK162/BKM120 combination and BIBW2997/ARQ197 combination therapy on cell apoptosis. H1975 (A), H460 (B), and A549 (C) cells were treated with 1 μM MEK162/5 μM BKM120 combination and 1 µM BIBW2992/2 µM ARQ 197 combination for 48 h. Control cells were treated with 0.05% DMSO. Cells were simultaneously stained with annexin V- FITC and PI, and the apoptosis rates were assessed by flow cytometry. Cells positive for annexin V-FITC and negative for PI were in early apoptosis

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BMC Pulmonary Medicine

ISSN: 1471-2466

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