Skip to main content

Table 4 Association of risk factors with severe adult-onset asthma by using a medication-based definition of severe asthma (Sev-OCS). Multivariate model

From: Risk factors for severe adult-onset asthma: a multi-factor approach

  Model 1
Univariate regression model
  Model 2
Multiple regression model
n = 1173
 
  OR1 (95% CI) p1 OR2 (95% CI) p2
Male sex     
No
Yes
1
1.20 (0.90–1.61)
.21 1
1.03 (0.73–1.46)
.87
Age1 1.008 (1.00–1.02) .20 1.012 (1.00–1.03) .092
BMI1 1.03 (1.00–1.06) .059 1.31 (0.92–1.87) .13
Baccalaureate/secondary school     
No
Yes
1
0.86 (0.63–1.17)
.33 Not entered  
Professional training     
No
Yes
1
0.81 (0.58–1.12)
.20 Not entered  
Ever smokers     
No
Yes
1
1.70 (1.25–2.31)
.001 1
1.69 (1.19–2.40)
.003
1st child     
No
Yes
1
1.37 (1.01–1.86)
.043 1
1.34 (0.96–1.86)
.088
 ≥ 2 siblings     
No
Yes
1
0.92 (0.65–1.29)
.62 Not entered  
Growing up in the countryside/on a farm     
No
Yes
1
0.72 (0.52–0.99)
.041 1
0.69 (0.48–0.99)
.046
Severe childhood infections2     
No
Yes
1
1.28 (0.89–1.84)
.19 1
1.03 (0.69–1.54)
.88
Parental smoking     
No
Yes
1
1.23 (0.92–1.64)
.16 1
1.24 (0.90–1.69)
.19
Parental asthma and/or allergy     
No
Yes
1
1.02 (0.75–1.37)
.92 Not entered  
NERD     
No
Yes
1
1.37 (0.89–2.11)
.15 1
1.68 (1.06–2.69)
.029
CRSwNP     
No
Yes
1
0.98 (0.62–1.54)
.92 Not entered  
 ≥ 1 other disease3     
No
Yes
1
1.73 (1.24–2.43)
.001 1
1.49 (1.03–2.18)
.037
 ≥ 1 other allergic disease (AR/AC/AD)     
No
Yes
1
1.14 (0.83–1.55)
.42 Not entered  
  1. Bold values denote statistical significance at the p < 0.05 level
  2. Model 1 = Univariate analysis. Model 2 = Multivariable analysis by the twelve variables that were associated at the p < 0.2 level in Model 1). In addition, we wanted to force age (p = 0.20) and sex (p = 0.021) in model 2 to obtain a more comparable model to the first model. Hence, a total of 10 variables were entered in a multivariable model. NERD = patient-reported NSAID-exacerbated respiratory disease; CRSwNP = chronic rhinosinusitis with nasal polyps; AR = allergic rhinitis; AC = allergic rhinoconjunctivitis, AD = atopic dermatitis. 1continuous variables. 2pneumonia before or during school age and/or hospitalization due to infection at ≤ 3 years of age. 3Hypertension (n = 298), coronary artery disease (n = 120), rheumatoid arthritis (n = 60), psychiatric disorder (n = 86), diabetes (n = 54), glaucoma (n = 49), back disease (n = 367), arthritis (n = 244), empyema (n = 106), other chronic disease(s) except chronic bronchitis/bronchiectasis (n = 449). Education level = baccalaureate/secondary versus primary school; professional training = completed professional college/university/courses/trade school versus no professional training. OR = odds ratio. CI = confidence interval. Severe asthma (Sev-OCS) was defined as those who reported regular use of oral corticosteroid in e and/or ≥ 2 corticosteroid courses/year due to asthma