Table 4 Association of risk factors with severe adult-onset asthma by using a medication-based definition of severe asthma (Sev-OCS). Multivariate model

Male sex

No

Yes

1

1.20 (0.90–1.61)

.21

1

1.03 (0.73–1.46)

.87

Age¹

1.008 (1.00–1.02)

.20

1.012 (1.00–1.03)

.092

BMI¹

1.03 (1.00–1.06)

.059

1.31 (0.92–1.87)

.13

Baccalaureate/secondary school

No

Yes

1

0.86 (0.63–1.17)

.33

Not entered

Professional training

No

Yes

1

0.81 (0.58–1.12)

.20

Not entered

Ever smokers

No

Yes

1

1.70 (1.25–2.31)

.001

1

1.69 (1.19–2.40)

.003

1st child

No

Yes

1

1.37 (1.01–1.86)

.043

1

1.34 (0.96–1.86)

.088

 ≥ 2 siblings

No

Yes

1

0.92 (0.65–1.29)

.62

Not entered

Growing up in the countryside/on a farm

No

Yes

1

0.72 (0.52–0.99)

.041

1

0.69 (0.48–0.99)

.046

Severe childhood infections²

No

Yes

1

1.28 (0.89–1.84)

.19

1

1.03 (0.69–1.54)

.88

Parental smoking

No

Yes

1

1.23 (0.92–1.64)

.16

1

1.24 (0.90–1.69)

.19

Parental asthma and/or allergy

No

Yes

1

1.02 (0.75–1.37)

.92

Not entered

NERD

No

Yes

1

1.37 (0.89–2.11)

.15

1

1.68 (1.06–2.69)

.029

CRSwNP

No

Yes

1

0.98 (0.62–1.54)

.92

Not entered

 ≥ 1 other disease³

No

Yes

1

1.73 (1.24–2.43)

.001

1

1.49 (1.03–2.18)

.037

 ≥ 1 other allergic disease (AR/AC/AD)

No

Yes

1

1.14 (0.83–1.55)

.42

Not entered