LINC01414/LINC00824 genetic polymorphisms in association with the susceptibility of chronic obstructive pulmonary disease

Table 3 Association between candidate SNPs and COPD susceptibility

SNP ID	Model	Genotype	Case	Control	Adjusted by age and gender
SNP ID	Model	Genotype	Case	Control	OR (95%CI)	p
LINC01414 rs6994670	Genotype	AA	194	166	1
		AG	107	123	0.75 (0.53–1.04)	0.085
		GG	14	24	0.51 (0.25–1.02)	0.056
	Dominant	AA	194	166	1
	Dominant	AG-GG	121	147	0.71 (0.51–0.97)	0.034*
	Recessive	AA-AG	301	289	1
	Recessive	GG	14	24	0.57 (0.29–1.13)	0.107
	Log-additive	–	–	–	0.73 (0.56–0.95)	0.018*
LINC01414 rs298207	Genotype	GG	192	201	1
		GA	94	99	1.00 (0.71–1.41)	0.990
		AA	24	9	2.87 (1.30–6.36)	0.009*
	Dominant	GG	192	201	1
	Dominant	GA-AA	118	108	1.15 (0.83–1.60)	0.400
	Recessive	GG-GA	286	300	1
	Recessive	AA	24	9	2.88 (1.31–6.31)	0.008*
	Log-additive	–	–	–	1.27 (0.97–1.66)	0.085
LINC00824 rs7815944	Genotype	AA	168	157	1
		AG	127	122	0.96 (0.69–1.34)	0.828
		GG	20	34	0.55 (0.30–0.99)	0.047*
	Dominant	AA	168	157	1
	Dominant	AG-GG	147	156	0.87 (0.64–1.20)	0.401
	Recessive	AA-AG	295	279	1
	Recessive	GG	20	34	0.56 (0.31–0.99)	0.046*
	Log-additive	–-	–-	–-	0.83 (0.65–1.06)	0.128

p values were calculated by logistic regression analysis adjusted by age and gender
Bold indicate that p < 0.05 means the data is statistically significant
COPD chronic obstructive pulmonary disease, SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval

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