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Table 4 Association between polymorphisms and COPD risk stratified by age and gender

From: LINC01414/LINC00824 genetic polymorphisms in association with the susceptibility of chronic obstructive pulmonary disease

SNP ID

Model

Genotype

Case

Control

OR (95%CI)

p

Case

Control

OR (95%CI)

p

Age

  

> 70 years

≤ 70 years

LINC01414

rs6994670

Allele

A

297

268

1

 

198

187

1

 

G

79

84

0.85 (0.60–1.20)

0.356

56

87

0.61 (0.41–0.90)

0.012*

Genotype

AA

116

102

1

 

78

64

1

 

AG

65

64

0.94 (0.59–1.47)

0.776

42

59

0.57 (0.33–0.97)

0.037*

GG

7

10

0.56 (0.20–1.57)

0.271

7

14

0.33 (0.12–0.90)

0.031*

Dominant

AA

116

102

1

 

78

64

1

 

AG-GG

72

74

0.88 (0.57–1.36)

0.569

49

73

0.52 (0.31–0.86)

0.012*

Recessive

AA-AG

181

166

1

 

120

123

1

 

GG

7

10

0.57 (0.21–1.59)

0.285

7

14

0.42 (0.16–1.12)

0.083

Log-additive

  

0.85 (0.59–1.23)

0.385

  

0.57 (0.38–0.86)

0.007*

LINC01414

rs298207

Allele

G

294

287

1

 

184

214

1

 

A

78

63

1.21 (0.84–1.75)

0.315

64

54

1.38 (0.91–2.08)

0.126

Genotype

GG

118

119

1

 

74

82

1

 

GA

58

49

1.24 (0.77–2.00)

0.379

36

50

0.84 (0.48–1.44)

0.521

AA

10

7

1.40 (0.50–3.90)

0.522

14

2

7.94 (1.69–37.21)

0.009*

Dominant

GG

118

119

1

 

74

82

1

 

GA-AA

68

56

1.26 (0.80–1.98)

0.317

50

52

1.1 (0.66–1.83)

0.726

Recessive

GG-GA

176

168

1

 

110

132

1

 

AA

10

7

1.31 (0.47–3.62)

0.602

14

2

8.47 (1.83–39.24)

0.006*

Log-additive

–-

  

1.21 (0.83–1.76)

0.311

  

1.38 (0.91–2.11)

0.134

LINC00824

rs7815944

Allele

A

278

235

1

 

185

201

1

 

G

98

117

0.71 (0.51–0.97)

0.034*

69

73

1.03 (0.70–1.51)

0.892

Genotype

AA

99

82

1

 

69

75

1

 

AG

80

71

0.90 (0.57–1.42)

0.653

47

51

1.02 (0.60–1.72)

0.951

GG

9

23

0.29 (0.12–0.68)

0.005*

11

11

1.03 (0.40–2.61)

0.956

Dominant

AA

99

82

1

 

69

75

1

 

AG-GG

89

94

0.75 (0.49–1.16)

0.193

58

62

1.02 (0.62–1.67)

0.943

Recessive

AA-AG

179

153

1

 

116

126

1

 

GG

9

23

0.30 (0.13–0.70)

0.005*

11

11

1.02 (0.41–2.53)

0.966

Log-additive

  

0.68 (0.48–0.95)

0.023*

  

1.02 (0.69–1.49)

0.941

Gender

  

Male

Female

LINC01414

rs298207

Allele

G

367

379

1

 

111

122

1

 

A

107

91

1.21 (0.89–1.66)

0.226

35

26

1.48 (0.84–2.61)

0.176

Genotype

GG

147

151

1

 

45

50

1

 

GA

73

77

0.98 (0.66–1.46)

0.932

21

22

1.06 (0.51–2.18)

0.878

AA

17

7

2.53 (1.02–6.28)

0.046*

7

2

3.99 (0.77–20.64)

0.099

Dominant

GG

147

151

1

 

45

50

1

 

GA-AA

90

84

1.11 (0.76–1.62)

0.582

28

24

1.29 (0.66–2.55)

0.456

Recessive

GG-GA

220

228

1

 

66

72

1

 

AA

17

7

2.54 (1.03–6.26)

0.043*

7

2

3.92 (0.77–20.00)

0.101

 

Log-additive

  

1.22 (0.89–1.66)

0.218

  

1.43 (0.82–2.46)

0.204

LINC00824

rs7815944

Allele

A

362

331

1

 

101

105

1

 

G

116

141

0.75 (0.56–1.00)

0.052

51

49

1.08 (0.67–1.75)

0.746

Genotype

AA

134

118

1

 

34

39

1

 

AG

94

95

0.87 (0.59–1.26)

0.454

33

27

1.41 (0.71–2.81)

0.332

GG

11

23

0.43 (0.20–0.91)

0.028*

9

11

0.94 (0.35–2.58)

0.912

Dominant

AA

134

118

1

 

34

39

1

 

AG-GG

105

118

0.78 (0.54–1.12)

0.179

42

38

1.28 (0.67–2.43)

0.457

Recessive

AA-AG

228

213

1

 

67

66

1

 

GG

11

23

0.45 (0.22–0.96)

0.037*

9

11

0.81 (0.31–2.08)

0.655

Log-additive

  

0.75 (0.56–1.00)

0.052

  

1.08 (0.68–1.71)

0.753

  1. p values were calculated by logistic regression analysis adjusted by age and gender
  2. Bold indicate that p < 0.05 means the data is statistically significant
  3. COPD chronic obstructive pulmonary disease, SNP single nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval