Table 5 Association between polymorphisms and COPD risk stratified by smoking
SNP ID | Model | Genotype | Case | Control | OR (95%CI) | p | Case | Control | OR (95%CI) | p | Case | Control | OR (95%CI) | p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Smoking | Current | Former | Never | |||||||||||
LINC00824 rs7815944 | Allele | A | 123 | 47 | 1 | 97 | 21 | 1 | 239 | 178 | 1 | |||
G | 43 | 21 | 0.78 (0.42–1.45) | 0.438 | 31 | 15 | 0.45 (0.21–0.97) | 0.040* | 93 | 58 | 1.19 (0.82–1.75) | 0.361 | ||
Genotype | AA | 43 | 16 | 1 | 36 | 8 | 1 | 87 | 65 | 1 | ||||
AG | 37 | 15 | 0.93 (0.40–2.15) | 0.867 | 25 | 5 | 1.08 (0.30–3.94) | 0.906 | 65 | 48 | 0.99 (0.6–1.62) | 0.966 | ||
GG | 3 | 3 | 0.36 (0.06–2.02) | 0.246 | 3 | 5 | 0.17 (0.03–0.96) | 0.044* | 14 | 5 | 1.96 (0.66–5.76) | 0.223 | ||
Dominant | AA | 43 | 16 | 1 | 36 | 8 | 1 | 87 | 65 | 1 | ||||
AG-GG | 40 | 18 | 0.83 (0.37–1.85) | 0.647 | 28 | 10 | 0.68 (0.21–2.14) | 0.506 | 79 | 53 | 1.08 (0.67–1.74) | 0.751 | ||
Recessive | AA-AG | 80 | 31 | 1 | 61 | 13 | 1 | 152 | 113 | 1 | ||||
GG | 3 | 3 | 0.37 (0.07–2.01) | 0.250 | 3 | 5 | 0.16 (0.03–0.84) | 0.031* | 14 | 5 | 1.97 (0.68–5.66) | 0.211 | ||
Log-additive | – | 0.76 (0.39–1.48) | 0.413 | 0.52 (0.22–1.20) | 0.124 | 1.17 (0.79–1.72) | 0.443 | |||||||