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Fig. 3 | BMC Pulmonary Medicine

Fig. 3

From: Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis

Fig. 3

MiR-26a-5p inhibited the progression of lung injury by regulating TLR4. A TLR4 expression in lung tissues of mice (n = 8 per group) was evaluated by RT-qPCR. B, C H&E staining (magnification: × 100) was conducted to assess the lung injury degree (n = 8 per group). D Statistical analysis revealed the lung wet/dry weight ratio (n = 8 per group). E, F RT-qPCR and ELISA were performed to evaluate the levels of TNF-α and IL-1β in lung tissues of mice (n = 8 per group). G, H RT-qPCR and ELISA were performed to evaluate the levels of TNF-α and IL-1β in PBECs. #P < 0.05 compared with AAV-vector group in A; #P < 0.05 compared with Sham + AAV-Mock + AAV-vector group, &P < 0.05 compared with ALI + AAV-Mock + AAV-vector group, @P < 0.05 compared with ALI + AAV-miR-26a-5p + AAV-vector group in C–F; #P < 0.05 compared with control + Mock + vector group, &P < 0.05 compared with LPS + Mock + vector group, @P < 0.05 compared with LPS + miR-26a-5p + vector group in G, H

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