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Fig. 6 | BMC Pulmonary Medicine

Fig. 6

From: Long non-coding RNA OIP5-AS1 aggravates acute lung injury by promoting inflammation and cell apoptosis via regulating the miR-26a-5p/TLR4 axis

Fig. 6

OIP5-AS1 promoted lung inflammation in ALI mice by regulating miR-26a-5p. A, B, H&E staining (magnification: × 100) was performed to detect the lung injury degree in ALI mice (n = 8 per group). C Statistical analysis revealed the lung wet/dry weight ratio (n = 8 per group). D–G RT-qPCR and ELISA were applied to assess the levels of TNF-α and IL-1β in serum of mice (n = 8 per group) and in supernatant of PBECs. #P < 0.05 compared with Sham + AAV-Mock + AAV-vector group, &P < 0.05 compared with ALI + AAV-Mock + AAV-vector group, @P < 0.05 compared with ALI + AAV-OIP5-AS1 + AAV-vector group in B–E; #P < 0.05 compared with control + Mock + vector group, &P < 0.05 compared with LPS + Mock + vector group, @P < 0.05 compared with LPS + OIP5-AS1 + vector group in F, G

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