Fig. 7

OIP5-AS1 accelerated cell apoptosis via regulating miR-26a-5p. A The protein expression of Bax and Bcl-2 in lung tissues of ALI mice (n = 8 per group) was assessed by western blot assay. B Relative activity of caspase-3 in lung tissues of ALI mice (n = 8 per group). C Flow cytometry assay was utilized to reveal cell apoptosis rate of PBECs. D The protein expression of apoptosis genes in PBECs was revealed by western blot assay. E The activity of caspase-3 in PBECs was detected. ^#P < 0.05 compared with Sham + AAV-Mock + AAV-vector group, ^&P < 0.05 compared with ALI + AAV-Mock + AAV-vector group, ^@P < 0.05 compared with ALI + AAV-OIP5-AS1 + AAV-vector group in A, B; ^#P < 0.05 compared with control + Mock + vector group, ^&P < 0.05 compared with LPS + Mock + vector group, ^@P < 0.05 compared with LPS + Mock + OIP5-AS1 group in C–E