Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study

BMC Pulmonary Medicine

Table 1 2-Sample MR, decreasing lung function effect on cognitive function

Lung function measure	No. of SNPs	Test used	Cognitive function
Lung function measure	No. of SNPs	Test used	Beta (SE)	p-value	Q_P-value
FEV₁, FVC, FEV₁/FVC, PEF	173	IVW	− 0.002 (0.02)	0.86	1.44 × 10¹¹
		Weighted median	0.02 (0.02)	0.44
		Weighted Mode	− 0.004 (0.03)	0.91
		MR Egger	− 0.005 (0.03)	0.90
FEV₁	59	IVW	− 0.05 (0.04)	0.44	1.8 × 10^–8
		Weighted median	− 0.02 (0.04)	0.46
		Weighted mode	− 0.05 (0.08)	0.51
		MR Egger	− 0.09 (0.1)	0.43
FVC	68	IVW	− 0.004 (0.03)	0.87	0.01
		Weighted median	− 0.02 (0.04)	0.51
		Weighted mode	− 0.03 (0.07)	0.65
		MR Egger	− 0.16 (0.10)	0.13
FEV₁/FVC	93	IVW	0.01 (0.02)	0.52	0.01
		Weighted median	0.02 (0.02)	0.52
		Weighted mode	0.007 (0.05)	0.87
		MR Egger	0.02 (0.04)	0.67

Negative beta indicates decreasing cognitive function
SE, standard error; Q_P-value, a measure of heterogeneity (p-value < 0.05 provides strong evidence of heterogeneity)

ISSN: 1471-2466