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Table 1 2-Sample MR, decreasing lung function effect on cognitive function

From: Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study

Lung function measure No. of SNPs Test used Cognitive function
Beta (SE) p-value Q_P-value
FEV1, FVC, FEV1/FVC, PEF 173 IVW − 0.002 (0.02) 0.86 1.44 × 1011
Weighted median 0.02 (0.02) 0.44
Weighted Mode − 0.004 (0.03) 0.91
MR Egger − 0.005 (0.03) 0.90
FEV1 59 IVW − 0.05 (0.04) 0.44 1.8 × 10–8
Weighted median − 0.02 (0.04) 0.46
Weighted mode − 0.05 (0.08) 0.51
MR Egger − 0.09 (0.1) 0.43
FVC 68 IVW − 0.004 (0.03) 0.87 0.01
Weighted median − 0.02 (0.04) 0.51
Weighted mode − 0.03 (0.07) 0.65
MR Egger − 0.16 (0.10) 0.13
FEV1/FVC 93 IVW 0.01 (0.02) 0.52 0.01
Weighted median 0.02 (0.02) 0.52
Weighted mode 0.007 (0.05) 0.87
MR Egger 0.02 (0.04) 0.67
  1. Negative beta indicates decreasing cognitive function
  2. SE, standard error; Q_P-value, a measure of heterogeneity (p-value < 0.05 provides strong evidence of heterogeneity)