Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study

BMC Pulmonary Medicine

Table 3 MVMR analysis results

Lung function measure	Condition	No SNPs (trait/condition)	Cognitive function
Lung function measure	Condition	No SNPs (trait/condition)	Beta (SE)	p-value
FEV₁	None	298/0	− 0.06 (0.03)	< 0.001
FEV₁	Height	212/299	− 0.03 (0.03)	0.29
FEV₁	BMI	180/629	− 0.07 (0.03)	0.03
FEV₁	Educational attainment	274/32	− 0.03 (0.03)	0.33
FVC	None	381/0	− 0.06 (0.01)	< 0.001
FVC	Height	278/314	− 0.01 (0.03)	0.62
FVC	BMI	224/595	− 0.05 (0.02)	0.004
FVC	Educational attainment	335/31	− 0.01 (0.02)	0.35

Effect of decreasing Lung function trait on cognitive function with and without conditioning for covariates
Negative beta indicates decreasing cognitive function
SE, standard error

ISSN: 1471-2466