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Table 3 Correlations imaging versus spirometry (n = 24)

From: Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis: a cross-sectional study

  Spirometry (% predicted)
FEV1 FVC Square of PEF Sqrt of MEF25–75 Log of MEF25
FRI
 iVlobe at TLC (L) NS NS NS NS NS
 iVlobe at FRC (L) − 0.72*** − 0.43* − 0.66*** − 0.77*** − 0.76***
 Log of siVaw at TLC (mL/L) NS NS NS NS NS
 Log of siVaww at TLC (mL/L) NS − 0.44* NS NS NS
 Log of siRaw at TLC (kPa * s/L) NS NS NS NS NS
 AT at FRC (%) − 0.85*** − 0.59** − 0.76*** − 0.88*** − 0.84***
 TBV at TLC (mL/L) NS NS NS NS NS
 BV10% at TLC (%) − 0.57** − 0.51* − 0.59** − 0.58** − 0.45*
 BV5_10% at TLC (%) − 0.61** − 0.59** − 0.49* − 0.54** − 0.55**
 Square of BV5% at TLC (%) 0.64*** 0.57** 0.62** 0.61** 0.52**
CF-CT
 Total score (%) − 0.85*** − 0.73*** − 0.65*** − 0.80*** − 0.81***
 Bronchiectasis (%) − 0.77*** − 0.70*** − 0.51* − 0.73*** − 0.73***
 Mucus plugging (%) − 0.80*** − 0.68*** − 0.69*** − 0.75*** − 0.77***
 BWT (%) − 0.61** − 0.58** NS − 0.50* − 0.58**
 Parenchyma (%) − 0.73*** − 0.77*** − 0.48* − 0.66*** − 0.66***
 AT (%) − 0.69*** − 0.54** − 0.61** − 0.65*** − 0.66***
  1. FRI: Pearson correlation coefficients, only iVlobe at FRC and AT at FRC were calculated using Spearman. CF-CT: Spearman correlation coefficients. *p < 0.05; **p < 0.01; ***p < 0.001
  2. iVlobe lobar volume, siVaw specific airway volume, siVaww specific airway wall volume, siRaw specific airway resistance, AT air trapping, TBV total pulmonary blood volume corrected for lobar volume, BV10% percentage of blood vessels larger than 10 mm2, BV5_10% percentage of blood vessels between 5 and 10 mm2, BV5% percentage of blood vessels smaller than 5 mm2, BWT bronchial wall thickening