Fig. 4

The distribution of asthma patients between high or low FeNO and B-Eos counts. A Venn diagram showing low or high FeNO and B-Eos counts in asthma patients. B Histogram analysis of low or high FeNO and B-Eos counts in asthma diagnosis. C Scatter plot of FeNO and B-Eos counts in asthma patients. D Scatter plot of FeNO and B-Eos counts in non-asthmatic patients. Notes: High or low FeNO were defined on the basis of a cutoff value of 40 ppb. Similarly, high or low B-Eos counts were defined on the basis of a cutoff value of 300 cells/μl. The red lines in C, D were drawn by linking different thresholds of FeNO and B-Eos counts to achieve the diagnosis goals of a positive likelihood ratio exceeding 10 and a diagnostic specificity exceeding 95%