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Table 2 Diagnostic accuracy of different combinations of threshold values of these two biomarkers (n = 2349)

From: Diagnostic possibility of the combination of exhaled nitric oxide and blood eosinophil count for eosinophilic asthma

Categories

Sensitivity (%)

Specificity (%)

PLR

NLR

PPV (%)

NPV (%)

FeNO > 20 ppb†

      

 B-Eos > 100 cells/μl*

69.71

64.25

1.9

0.5

51.31

79.70

 B-Eos > 200 cells/μl*

56.07

81.10

3.0

0.5

61.58

77.36

 B-Eos > 300 cells/μl*

41.83

89.93

4.2

0.6

69.18

74.10

 B-Eos > 400 cells/μl*

31.89

93.22

4.7

0.7

71.77

71.70

 B-Eos > 500 cells/μl*

22.57

95.55

5.1

0.8

73.25

69.55

FeNO > 30 ppb†

      

 B-Eos > 100 cells/μl*

58.95

80.39

3.0

0.5

61.89

78.38

 B-Eos > 200 cells/μl*

47.42

89.63

4.6

0.6

71.19

75.93

 B-Eos > 300 cells/μl*

35.38

94.47

6.4

0.7

77.58

73.01

 B-Eos > 400 cells/μl*

26.97

96.28

7.3

0.8

79.67

70.93

 B-Eos > 500 cells/μl*

19.09

97.56

7.8

0.8

80.85

69.05

FeNO > 40 ppb†

      

 B-Eos > 100 cells/μl*

50.98

90.38

5.3

0.5

74.12

77.33

 B-Eos > 200 cells/μl*

41.00

94.92

8.1

0.6

81.33

74.86

 B-Eos > 300 cells/μl*

30.59

97.29

11.3

0.7

85.92

72.18

 B-Eos > 400 cells/μl*

23.32

98.18

12.8

0.8

87.36

70.32

 B-Eos > 500 cells/μl*

16.51

98.80

13.8

0.8

88.16

68.65

FeNO > 50 ppb†

      

 B-Eos > 100 cells/μl*

43.09

93.87

7.0

0.6

79.16

75.32

 B-Eos > 200 cells/μl*

34.66

96.76

10.7

0.7

85.25

73.27

 B-Eos > 300 cells/μl*

25.86

98.27

15.0

0.8

89.00

71.04

 B-Eos > 400 cells/μl*

19.72

98.84

17.0

0.8

90.16

69.50

 B-Eos > 500 cells/μl*

13.95

99.24

18.3

0.9

90.80

68.10

FeNO > 60 ppb†

      

 B-Eos > 100 cells/μl*

35.31

96.09

9.0

0.7

83.00

73.33

 B-Eos > 200 cells/μl*

28.40

97.93

13.7

0.7

88.13

71.68

 B-Eos > 300 cells/μl*

21.19

98.90

19.2

0.8

91.23

69.90

 B-Eos > 400 cells/μl*

16.16

99.26

21.8

0.8

92.17

68.66

 B-Eos > 500 cells/μl*

11.43

99.51

23.5

0.9

92.69

67.53

FeNO > 70 ppb†

      

 B-Eos > 100 cells/μl*

28.76

97.62

12.1

0.7

86.73

71.72

 B-Eos > 200 cells/μl*

23.13

98.74

18.4

0.8

90.86

70.39

 B-Eos > 300 cells/μl*

17.26

99.33

25.8

0.8

93.30

68.96

 B-Eos > 400 cells/μl*

13.16

99.55

29.2

0.9

94.04

67.96

 B-Eos > 500 cells/μl*

9.31

99.70

31.4

0.9

94.44

67.05

FeNO > 80 ppb†

      

 B-Eos > 100 cells/μl*

24.26

98.35

14.7

0.8

88.83

70.62

 B-Eos > 200 cells/μl*

19.51

99.13

22.4

0.8

92.37

69.51

 B-Eos > 300 cells/μl*

14.56

99.54

31.4

0.9

94.43

68.31

 B-Eos > 400 cells/μl*

11.10

99.69

35.5

0.9

95.05

67.48

 B-Eos > 500 cells/μl*

7.85

99.79

38.3

0.9

95.39

66.72

FeNO > 90 ppb†

      

 B-Eos > 100 cells/μl*

19.75

98.85

17.2

0.8

90.26

69.51

 B-Eos > 200 cells/μl*

15.89

99.39

26.1

0.8

93.38

68.62

 B-Eos > 300 cells/μl*

11.85

99.68

36.6

0.9

95.18

67.67

 B-Eos > 400 cells/μl*

9.04

99.78

41.4

0.9

95.72

67.00

 B-Eos > 500 cells/μl*

6.40

99.86

44.6

0.9

96.02

66.38

FeNO > 38 ppb‡

      

 B-Eos > 203 cells/μl‡

42.18

94.41

7.6

0.6

80.31

75.14

  1. †Baseline screening value of the former biomarker
  2. *Progressively increasing cutoff values of the combined biomarkers
  3. ‡The optimal diagnostic cutoff value for each biomarker alone
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BMC Pulmonary Medicine

ISSN: 1471-2466

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