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Table 3 Demographics, clinical characteristics, laboratory data, treatments, complications, and prognosis of AKI versus non-AKI patients with ARDS caused by bacterial pneumonia

From: Deep vein thrombosis in acute respiratory distress syndrome caused by bacterial pneumonia

Variables

Total (n = 90)

AKI (n = 46)

Non-AKI (n = 44)

P value

Age (years)

68 (57, 78)

72 (59, 80)

66 (55, 76)

0.116

Male, n (%)

69 (76.6)

36 (78.3)

33 (75.0)

0.715

BMI

23.8 ± 4.0

23.6 ± 3.9

24.0 ± 4.1

0.606

CKD, n (%)

6 (6.7)

6 (13.0)

0 (0)

0.026

APACHE II score

22 (19, 28)

27 (22, 31)

19 (15, 23)

 < 0.001

SIRS score

15 (13,16)

15 (14, 18)

13 (12, 15)

 < 0.001

Laboratory data

    

Scr (μmol/L)

89.8 (66.0, 194.6)

191.4 (123.4, 290.2)

66.9 (52.5, 78.4)

 < 0.001

Ccr (mL/min)

55.9 (29.4, 97.6)

30.9 (20.5, 40.8)

98.2 (67.6, 118.2)

 < 0.001

WBC (× 109/L)

15.3 (11.6, 21.4)

17.4 (12.1, 23.0)

13.7 (11.2, 18.1)

0.033

Platelets (× 109/L)

194 (126, 300)

180 (88, 255)

242 (143, 326)

0.014

Procalcitonin (ng/mL)

1.6 (0.4, 9.7)

5.4(1.2, 14.0)

0.6 (0.1, 2.6)

 < 0.001

D-dimer (mg/L)

2.0 (0.9, 4.7)

2.3 (1.0, 4.9)

1.8 (0.6, 4.0)

0.155

PT (s)

13.9 (12.1, 16.0)

14.6 (12.2, 18.8)

13.4 (11.9, 15.5)

0.063

APTT (s)

32.3 (29.2, 36.0)

34.4 (29.6, 46.3)

31.0 (29.0, 33.7)

0.011

PaO2/FiO2

132 ± 60

120 ± 57

145 ± 60

0.046

Treatments

    

CVC, n (%)

35 (38.9)

24 (52.2)

11 (25.0)

0.008

CRRT, n (%)

10 (11.1)

9 (19.6)

1 (2.3)

0.015

Sedative therapy, n (%)

40 (44.4)

26 (56.5)

14 (31.8)

0.018

IMV, n (%)

54 (60.0)

32 (69.6)

22 (50.0)

0.058

VTE prophylaxis, n (%)

41 (45.6)

27 (58.7)

14 (31.8)

0.010

LMWH, n (%)

35 (38.9)

22 (47.8)

13 (29.5)

0.075

LMWH + physical prophylaxis, n (%)

26 (28.9)

16 (34.8)

10 (22.7)

0.207

Physical prophylaxis only, n (%)

4 (4.4)

4 (8.7)

0 (0)

0.117

Major complications

    

ACI, n (%)

39 (43.3)

27 (58.7)

12 (27.3)

0.003

Sepsis, n (%)

87 (96.7)

45 (97.8)

42 (95.5)

0.612

Septic shock, n (%)

39 (43.3)

27 (58.7)

12 (27.3)

0.003

ALI, n (%)

43 (47.8)

25 (54.3)

18 (40.9)

0.202

DVT, n (%)

40 (44.4)

17 (37.0)

23 (52.3)

0.144

Number of US scan

1 (1, 2)

2 (1, 3)

1 (1, 2)

0.023

Duration to DVT or last negative US scan (days)

5 (2, 12)

5 (1, 13)

6 (3, 11)

0.436

Mortality, n (%)

38 (42.2)

27 (58.7)

11 (25.0)

0.001

  1. ARDS, acute respiratory distress syndrome; AKI, acute kidney injury; BMI, body mass index; CKD, chronic kidney disease; APACHE II, Acute Physiology and Chronic Health Evaluation; SIRS, systemic inflammatory response syndrome; Scr, serum creatinine; Ccr, creatinine clearance rate; WBC, white blood cells; PT, prothrombin time; APTT, activated partial prothrombin time; PaO2, partial pressure of arterial oxygen; FiO2, fraction of inspired oxygen; CVC, central venous catheterization; CRRT, continuous renal replacement therapy; IMV, invasive mechanical ventilation; VTE, venous thromboembolism; LMWH, low molecular weight heparin; ACI, acute cardiac injury; ALI, acute liver injury; DVT, deep vein thrombosis; US, ultrasonic
  2. Data are the mean ± SD, median (IQR) or n (%). P values comparing AKI and non-AKI were from the 2-sample t test, Mann–Whitney U test, χ2 test, or Fisher’s exact test. P < 0.05 was considered statistically significant
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BMC Pulmonary Medicine

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