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Table 2 Differences of immune parameters in untreated lung cancer patients and healthy controls

From: Circulating activated immune cells as a potential blood biomarkers of non-small cell lung cancer occurrence and progression

Lymphocyte subsets Healthy controls (N = 132) Lung cancer patients (N = 357) P value
T Lymphocyte (cells/10^12ul) 1.97 ± 0.53 1.73 ± 0.61  < 0.001
B cells (cells/ul) 201.69 ± 91.56 184.85 ± 98.29 0.054
NK cells (cells/ul) 390.99 ± 251.48 269.15 ± 213.78  < 0.001
CD4+ T cells (cells/ul) 689.83 ± 255.28 745 ± 302.8 0.042
CD8+ T cells (cells/ul) 511.43 ± 255.09 439.25 ± 212.9 0.008
Memory CD4+/CD4+ (%) 65.89 ± 13.8 73.55 ± 12.88  < 0.001
Memory CD4+ T cells (cells/ul) 441.8 ± 166.31 539.09 ± 220.41  < 0.001
Naïve CD4+/CD4+ (%) 34.11 ± 13.8 24.21 ± 12.2  < 0.001
Naïve CD4+ T cells (cells/ul) 248.05 ± 160.27 183.7 ± 128.13  < 0.001
CD4+CD28+/CD4+ (%) 87.12 ± 10.97 92.42 ± 8.95  < 0.001
CD4+CD28+ T cells (cells/ul) 600.64 ± 239.99 674.78 ± 271.48 0.002
CD8+CD28+/CD8+ (%) 50.95 ± 15.54 55.84 ± 17.26 0.004
CD8+CD28+ T cells (cells/ul) 249.24 ± 119.32 230.43 ± 106.65 0.156
CD8+HLA-DR+/CD8+ (%) 28.4 ± 10.7 38.37 ± 14.13  < 0.001
CD8+HLA-DR+ T cells (cells/ul) 148.75 ± 102.86 175.18 ± 129.29 0.022
CD8+CD38+/CD8+ (%) 22.34 ± 14.71 31.04 ± 13.35  < 0.001
CD8+CD38+ T cells (cells/ul) 114.11 ± 96.19 136.43 ± 95.69 0.001
CD4+/CD8+ (%) 1.62 ± 0.91 1.97 ± 1.00  < 0.001
  1. Bold represents p <0.05, the difference was statistically significant