Table 3 Relationship between lymphocytes levels and clinicopathologic characteristics

Gender

 Male

1220.79 ± 428.8

162.41 ± 92.49

294.41 ± 257.20

733.74 ± 329.37

443.59 ± 215.88

74.40 ± 13.31

532.37 ± 227.24

22.94 ± 11.97

169.68 ± 122.10

91.99 ± 9.66

649.61 ± 268.00

53.9 ± 17.42

224.69 ± 105.81

39.77 ± 14.11

184.25 ± 135.22

30.16 ± 13.31

135.34 ± 102.45

1.95 ± 1.14

 Female

1277.29 ± 474.83

204.14 ± 99.30

247.43 ± 165.50

754.67 ± 278.59

435.51 ± 210.90

72.81 ± 12.50

544.86 ± 214.89

25.30 ± 12.32

195.75 ± 132.28

92.80 ± 8.30

696.41 ± 273.39

57.51 ± 16.99

235.36 ± 107.43

37.16 ± 14.07

167.39 ± 123.85

31.79 ± 13.37

137.36 ± 89.77

1.99 ± 0.88

 P

0.431

 < 0.001

0.318

0.287

0.657

0.226

0.226

0.560

0.122

0.067

0.360

0.120

0.047

0.401

0.084

0.129

0.203

0.141

Age

 Yong

1220.60 ± 432.39

184.20 ± 96.01

239.06 ± 178.45

665.40 ± 311.44

464.27 ± 211.49

70.42 ± 12.80

450.16 ± 161.82

28.35 ± 12.75

207.01 ± 186.37

95.36 ± 4.36

611.66 ± 327.88

65.3 ± 13.68

288.07 ± 118.46

29.66 ± 11.17

143.33 ± 95.13

38.78 ± 13.86

174.12 ± 92.71

1.71 ± 0.92

 Middle

1274.92 ± 452.69

193.84 ± 103.67

261.69 ± 203.82

745.08 ± 269.35

449.80 ± 219.66

73.16 ± 12.48

542.60 ± 217.98

25.27 ± 12.33

190.65 ± 122.15

92.76 ± 8.42

689.79 ± 256.35

57.03 ± 17.84

238.78 ± 102.11

37.58 ± 13.74

178.92 ± 133.65

32.53 ± 13.13

143.6 ± 86.67

1.90 ± 0.85

 Elder

1239.03 ± 460.52

178.59 ± 94.77

279.02 ± 225.75

757.07 ± 323.13

427.96 ± 208.82

74.29 ± 13.17

550.16 ± 227.77

22.84 ± 11.88

175.23 ± 121.60

91.73 ± 9.73

673.78 ± 272.92

53.56 ± 16.83

215.74 ± 104.94

40.25 ± 14.32

177.39 ± 130.65

28.80 ± 12.90

125.61 ± 100.69

2.06 ± 1.11

 P

0.688

0.550

0.446

0.152

0.425

0.275

0.077

0.055

0.338

0.121

0.169

0.006

0.003

0.002

0.521

 < 0.001

0.001

0.123

Allergic history

 Antibiotic

1247.95 ± 325.87

179.33 ± 111.83

213.09 ± 121.54

714.35 ± 243.96

447.59 ± 190.59

75.65 ± 11.83

533.42 ± 183.06

21.00 ± 11.73

159.85 ± 119.09

91.83 ± 10.97

640.66 ± 273.15

60.33 ± 17.27

250.68 ± 90.57

35.95 ± 15.01

169.99 ± 135.4

33.17 ± 16.32

146.63 ± 107.45

1.89 ± 1.07

 Other

1397.30 ± 255.23

286.59 ± 60.68

245.97 ± 195.28

834.23 ± 210.96

475.6 ± 76.96

69.81 ± 9.10

590.88 ± 217.92

28.21 ± 10.03

226.12 ± 79.85

94.97 ± 2.95

795.26 ± 213.46

66.68 ± 9.31

320.55 ± 85.93

26.80 ± 5.40

126.96 ± 30.38

28.72 ± 11.96

137.68 ± 68.03

1.76 ± 0.36

 No

1245.96 ± 478.24

184.37 ± 96.29

260.92 ± 195.87

752.53 ± 319.46

433.62 ± 209.25

73.03 ± 13.24

540.24 ± 231.06

24.81 ± 12.38

188.6 ± 131.45

92.42 ± 8.83

683.06 ± 276.73

55.43 ± 17.11

227.6 ± 109.03

38.18 ± 13.92

171.09 ± 120.46

30.92 ± 13.24

133.85 ± 91.74

1.99 ± 1.01

 P

0.431

0.018

0.568

0.527

0.417

0.323

0.780

0.138

0.158

0.975

0.367

0.107

0.026

0.033

0.747

0.807

0.751

0.723

Surgery

 Yes

1285.26 ± 471.23

182.04 ± 95.87

269.73 ± 203.91

749.71 ± 321.18

461.57 ± 221.21

73.04 ± 14.00

531.97 ± 210.35

24.12 ± 12.70

185.17 ± 136.17

91.56 ± 9.34

671.28 ± 269.38

53.28 ± 17.43

230.14 ± 108.07

39.62 ± 14.65

190.36 ± 136.55

32.75 ± 13.90

151.70 ± 106.33

1.88 ± 0.98

 No

1231.11 ± 436.88

187.04 ± 98.35

245.17 ± 178.12

752.79 ± 294.67

421.08 ± 203.97

73.73 ± 11.76

553.58 ± 238.93

24.55 ± 11.76

186.15 ± 121.17

93.30 ± 8.54

687.78 ± 284.41

58.65 ± 17.11

234.36 ± 109.49

36.27 ± 13.26

158.90 ± 122.38

28.62 ± 11.73

118.04 ± 72.55

2.09 ± 1.07

 P

0.428

0.866

0.272

0.708

0.098

0.898

0.456

0.552

0.653

0.141

0.543

0.008

0.593

0.072

0.019

0.014

0.013

0.039

History of diseases

 No

1301.63 ± 413.78

187.44 ± 97.57

294.99 ± 271.76

752.48 ± 256.8

462.89 ± 233.94

73.22 ± 12.76

545.68 ± 193.04

25.08 ± 12.72

193.87 ± 139.93

91.08 ± 8.93

686.59 ± 249.44

55.50 ± 16.87

238.56 ± 106.90

38.49 ± 14.95

185.52 ± 142.82

33.55 ± 12.46

154.74 ± 96.26

2.00 ± 1.07

 Yes

1234.46 ± 470.19

183.60 ± 96.63

252.92 ± 188.98

747.32 ± 322.23

431.22 ± 204.75

73.54 ± 13.19

539.69 ± 233.47

23.99 ± 12.24

181.21 ± 124.61

93.01 ± 8.92

674.79 ± 283.1

56.31 ± 17.74

229.26 ± 108.56

38.13 ± 14.15

170.82 ± 125.08

30.13 ± 13.64

128.74 ± 90.76

1.98 ± 1.00

 P

0.318

0.670

0.196

0.600

0.453

0.808

0.566

0.601

0.468

0.043

0.629

0.644

0.541

0.741

0.455

0.012

0.022

0.864

Smoking history

 No

1249.36 ± 463.71

194.16 ± 98.74

240.88 ± 167.3

744.68 ± 317.46

436.33 ± 214.38

72.58 ± 13.3

528.07 ± 217.8

25.19 ± 12.45

191.36 ± 137.93

92.66 ± 8.77

672.86 ± 272.05

55.95 ± 17.32

228.75 ± 105.67

37.11 ± 13.89

168.54 ± 130.16

31.02 ± 12.18

134.95 ± 87.04

1.95 ± 0.97

 Yes

1395.45 ± 460.14

204.81 ± 106.52

267.17 ± 174.27

854.83 ± 322.1

471.48 ± 185.99

74.52 ± 11.83

541.63 ± 201.09

22.63 ± 11.47

167.39 ± 103.98

91.2 ± 9.42

653.13 ± 253.27

54.51 ± 15.95

228.12 ± 105.94

39.96 ± 14.98

185.87 ± 139.02

30.78 ± 14.5

138.87 ± 111.4

2.01 ± 0.86

 Cessation

1220.78 ± 388.34

151.82 ± 90.12

329.4 ± 260.19

728.75 ± 246.2

441.08 ± 209.86

75.07 ± 12.07

634.99 ± 265.64

23.24 ± 12.14

204.1 ± 122.55

93.16 ± 9.43

791.84 ± 313.28

58.35 ± 18.73

264.2 ± 115.09

37.68 ± 13.03

185.99 ± 109.14

26.63 ± 10.94

122.51 ± 78.83

2.05 ± 1.17

 P

0.124

0.007

0.170

0.086

0.343

0.527

0.062

0.382

0.377

0.136

0.088

0.638

0.200

0.437

0.179

0.133

0.767

0.882

Drinking history

 No

1261.05 ± 464.45

194.59 ± 103.37

248.44 ± 175.23

752.68 ± 323.32

451.27 ± 223.03

73.12 ± 13.24

541.44 ± 234.83

24.47 ± 12.37

185.61 ± 130.73

92.61 ± 9.08

678.53 ± 287.05

55.91 ± 17.39

237.64 ± 113.07

38.02 ± 14.7

180.04 ± 139.59

31.42 ± 13.64

140.47 ± 95.31

1.92 ± 0.98

 Yes

1261.86 ± 459.97

160.90 ± 77.59

303.90 ± 251.43

762.52 ± 255.07

409.57 ± 187.12

77.26 ± 14.85

528.60 ± 176.76

20.22 ± 14.72

151.40 ± 132.36

91.04 ± 6.82

636.21 ± 206.03

55.11 ± 12.18

231.52 ± 67.87

37.27 ± 9.00

154.28 ± 35.43

29.04 ± 10.35

120.53 ± 43.69

2.22 ± 1.13

 Abstinence

1193.52 ± 242.43

124.90 ± 67.65

219.10 ± 116.42

698.20 ± 219.11

426.90 ± 104.67

72.98 ± 12.51

547.67 ± 185.77

25.24 ± 12.38

200.74 ± 131.11

91.99 ± 8.7

699.64 ± 244.28

55.65 ± 17.8

212.66 ± 90.33

38.86 ± 13.23

162.34 ± 104.68

29.20 ± 12.78

122.15 ± 94.93

1.76 ± 0.80

 P

0.902

0.020

0.651

0.589

0.542

0.454

0.738

0.364

0.312

0.291

0.626

0.937

0.438

0.676

0.925

0.458

0.177

0.152

ECOG PS

 0

1249.01 ± 470.92

189.54 ± 97.22

256.76 ± 188.20

755.79 ± 314.37

433.64 ± 208.84

73.07 ± 13.01

542.99 ± 227.84

24.55 ± 12.23

188.23 ± 130.96

92.41 ± 9.11

687.18 ± 275.96

56.88 ± 17.01

233.15 ± 108.53

37.34 ± 14.28

168.51 ± 125.77

30.31 ± 12.37

129.85 ± 84.49

2.00 ± 1.00

 1

1269.76 ± 376.02

157.46 ± 88.47

314.7 ± 345.09

723.17 ± 241.1

463.12 ± 259.22

74.22 ± 12.16

531.84 ± 187.04

24.57 ± 11.79

181.96 ± 110.51

93.97 ± 5.72

638.85 ± 261.14

51.87 ± 18.1

214.82 ± 99.14

40.64 ± 13.28

194.72 ± 158.1

33.24 ± 15.22

161.51 ± 137.98

2.02 ± 1.15

 2

1202.74 ± 242.49

181.56 ± 165.45

390.44 ± 282.96

632.00 ± 218.54

422.78 ± 129.95

77.45 ± 16.10

462.00 ± 79.90

19.88 ± 15.63

153.11 ± 176.08

88.14 ± 14.21

572.20 ± 257.73

49.58 ± 18.76

199.06 ± 87.64

44.74 ± 13.11

197.60 ± 117.35

38.93 ± 18.6

177.33 ± 133.09

1.58 ± 0.57

 3

1268 ± 534.57

257 ± 96.17

312 ± 91.92

633.5 ± 297.69

589 ± 260.22

90.59 ± 3.75

579.5 ± 293.45

7.69 ± 4.51

42.00 ± 5.66

96.05 ± 0.49

608 ± 282.84

52.1 ± 10.04

294 ± 76.37

45.05 ± 13.51

283 ± 196.58

20.95 ± 7.42

133.5 ± 98.29

1.07 ± 0.04

 P

0.966

0.093

0.267

0.541

0.776

0.138

0.779

0.115

0.075

0.881

0.617

0.264

0.395

0.104

0.427

0.280

0.705

0.188

Histology

 LAC

1239.83 ± 463.04

186.72 ± 98.1

262.97 ± 207.77

741.78 ± 309.04

432.47 ± 215.11

73.16 ± 12.97

533.68 ± 223.57

24.59 ± 12.26

185.23 ± 129.68

92.36 ± 9.22

669.8 ± 275.26

55.87 ± 17.38

226.45 ± 107.45

38.19 ± 14.1

171.93 ± 129.37

31.34 ± 12.95

135.01 ± 90.69

2.00 ± 1.03

 LSC

1355.94 ± 346.96

161.44 ± 98.52

308.93 ± 241.53

766.33 ± 231.97

508.07 ± 182.7

78.18 ± 10.83

593.22 ± 184.44

19.62 ± 10.23

157.22 ± 97.15

92.73 ± 5.56

711.58 ± 223.72

54.83 ± 16.04

266.91 ± 91.29

40.11 ± 14.84

208.43 ± 128.57

28.67 ± 16.78

153.82 ± 138.5

1.69 ± 0.73

 LASC

1562.36

298.00

909.00

1060.00

459.00

54.34

576.00

44.72

474.00

100.00

1060

75.90

348.38

38.70

177.63

12.60

57.83

2.31

 P

0.189

0.111

0.206

0.299

0.071

0.034

0.189

0.034

0.178

0.132

0.185

0.430

0.031

0.908

0.121

0.072

0.492

0.336

Tumor stage

 T1

1287.03 ± 461.46

199.48 ± 97.84

251.40 ± 185.00

771.03 ± 306.11

452.45 ± 209.34

72.5 ± 12.94

548.64 ± 209.38

25.08 ± 12.12

195.9 ± 134.25

92.84 ± 8.03

700.98 ± 270.52

55.8 ± 16.78

241.11 ± 109.81

37.68 ± 13.55

175.94 ± 127.54

29.33 ± 11.65

132.03 ± 81.94

1.93 ± 0.92

 T2

1132.15 ± 467.27

151.1 ± 86.35

237.71 ± 174.92

651.4 ± 307.11

393.92 ± 221.18

75.83 ± 11.66

486.99 ± 232.91

22.24 ± 11.46

151.16 ± 110.95

91.5 ± 9.2

580.82 ± 302.24

57.08 ± 17.45

206.53 ± 106.04

38.86 ± 14.46

161.27 ± 128.67

32.53 ± 14.45

128.38 ± 103.22

2.00 ± 1.03

 T3

1249.3 ± 474.78

138.25 ± 67.27

306.25 ± 230.88

766.37 ± 303.9

410.42 ± 206.36

78.33 ± 10.56

598.67 ± 258.33

20.01 ± 10.82

155.53 ± 92.08

93.41 ± 5.16

715.91 ± 297.6

59.04 ± 16.63

226.78 ± 116.11

36.41 ± 13.99

164.79 ± 133.54

29.23 ± 13.01

120.75 ± 104.33

2.17 ± 0.80

 T4

1226.94 ± 342.63

167.96 ± 107.62

349.64 ± 223.54

725.14 ± 207.8

427 ± 229.09

75.31 ± 12.43

541.55 ± 176.54

22.98 ± 12.26

170.36 ± 102.28

92.89 ± 9.07

670.33 ± 195.47

53.65 ± 21.62

199.97 ± 80.2

40.49 ± 14.87

173.75 ± 117.93

35.83 ± 15.59

163.63 ± 144.56

2.17 ± 1.28

P

0.085

0.002

0.093

0.033

0.257

0.142

0.100

0.188

0.129

0.923

0.016

0.702

0.088

0.612

0.669

0.191

0.430

0.532

Lymph nodes metastases

 N0

1273.8 ± 446.29

195.1 ± 97.38

251.71 ± 181.65

768.04 ± 303.92

441.54 ± 198.47

72.86 ± 12.89

549.78 ± 211.12

24.95 ± 12.09

193.59 ± 131.95

93.11 ± 7.56

697.13 ± 272.62

57.11 ± 16.46

241.44 ± 109.47

37.11 ± 13.59

168.68 ± 117.45

29.45 ± 11.66

128.97 ± 77.58

1.96 ± 0.93

 N1

1400.43 ± 633.16

212.75 ± 108.69

282.25 ± 206.57

779.17 ± 316.94

472.25 ± 267.66

76.96 ± 13.38

583.42 ± 222.68

21.28 ± 13.32

179.58 ± 140.93

90.83 ± 11.91

698.56 ± 266.3

51.27 ± 20.07

215.31 ± 91.73

40.2 ± 12.8

197.74 ± 138.02

33.98 ± 19.63

155.51 ± 121.06

1.91 ± 0.86

 N2

1241.51 ± 463.87

158.63 ± 85.08

254.33 ± 146.18

686.63 ± 320.14

477.71 ± 276.70

75.19 ± 11.33

511.32 ± 248.97

21.63 ± 10.81

154.41 ± 107.8

90.83 ± 9.74

630.08 ± 318.86

50.32 ± 17.87

217.47 ± 116.06

41.15 ± 14.88

213.69 ± 183.42

30.12 ± 14.02

149.22 ± 131.7

1.84 ± 1.01

 N3

1068.74 ± 429.88

136.71 ± 91.75

271.63 ± 179.01

650.58 ± 231.06

360.04 ± 211.56

74.49 ± 13.07

478.46 ± 182.73

23.75 ± 12.99

161.13 ± 110.39

91.98 ± 9.08

595.73 ± 212.16

56.8 ± 20.42

180.36 ± 78.89

40.46 ± 14.02

147.53 ± 108.87

36.11 ± 13.48

140.09 ± 133.64

2.23 ± 1.22

 P

0.248

0.008

0.729

0.127

0.115

0.545

0.227

0.385

0.266

0.556

0.152

0.202

0.030

0.217

0.492

0.114

0.936

0.696

Distant metastases

 M0

1281.78 ± 462.6

193.06 ± 97.13

254.16 ± 190.11

763.80 ± 308.98

448.96 ± 214.58

73.1 ± 12.83

548.94 ± 218.46

24.6 ± 12.05

190.51 ± 131

93.00 ± 7.89

694.48 ± 279.02

56.38 ± 16.78

239.97 ± 110.12

37.69 ± 13.94

175.8 ± 131.19

29.61 ± 12.1

132.35 ± 87.17

1.94 ± 0.91

 M1

1141.48 ± 396.68

145.72 ± 90.52

330.67 ± 302.36

671.32 ± 279.37

397.7 ± 198.3

75.95 ± 12.17

507.09 ± 242.88

21.89 ± 12.04

149.67 ± 101.18

88.73 ± 13.12

583.34 ± 219.81

52.2 ± 18.79

186.2 ± 81.8

40.76 ± 12.99

168.68 ± 109.18

35.05 ± 15.59

146.02 ± 121.53

2.12 ± 1.40

 P

0.099

0.001

0.049

0.040

0.121

0.278

0.103

0.208

0.049

0.040

0.015

0.099

0.001

0.065

0.827

0.053

0.908

0.926