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Table 3 Relationship between lymphocytes levels and clinicopathologic characteristics

From: Circulating activated immune cells as a potential blood biomarkers of non-small cell lung cancer occurrence and progression

  T lymphocytes (cells/ul) B cells (cells/ul) NK cells (cells/ul) CD4+ T cells (cells/ul) CD8+ T cells (cells/ul) Memory CD4+/CD4+ (%) Memory CD4+ T cells (cells/ul) Naïve CD4+/ CD4+ (%) Naïve CD4+ T cells (cells/ul) CD4+CD28+/CD4+ (%) CD4+CD28+ T cells (cells/ul) CD8+CD28+/CD8+ (%) CD8+CD28+ T cells (cells/ul) CD8+HLA-DR/ CD8+ (%) CD8+HLA-DR T cells (cells/ul) CD8+CD38+/CD8+ (%) CD8+CD38+ T cells (cells/ul) CD4+/CD8+
Gender
 Male 1220.79 ± 428.8 162.41 ± 92.49 294.41 ± 257.20 733.74 ± 329.37 443.59 ± 215.88 74.40 ± 13.31 532.37 ± 227.24 22.94 ± 11.97 169.68 ± 122.10 91.99 ± 9.66 649.61 ± 268.00 53.9 ± 17.42 224.69 ± 105.81 39.77 ± 14.11 184.25 ± 135.22 30.16 ± 13.31 135.34 ± 102.45 1.95 ± 1.14
 Female 1277.29 ± 474.83 204.14 ± 99.30 247.43 ± 165.50 754.67 ± 278.59 435.51 ± 210.90 72.81 ± 12.50 544.86 ± 214.89 25.30 ± 12.32 195.75 ± 132.28 92.80 ± 8.30 696.41 ± 273.39 57.51 ± 16.99 235.36 ± 107.43 37.16 ± 14.07 167.39 ± 123.85 31.79 ± 13.37 137.36 ± 89.77 1.99 ± 0.88
 P 0.431  < 0.001 0.318 0.287 0.657 0.226 0.226 0.560 0.122 0.067 0.360 0.120 0.047 0.401 0.084 0.129 0.203 0.141
Age
 Yong 1220.60 ± 432.39 184.20 ± 96.01 239.06 ± 178.45 665.40 ± 311.44 464.27 ± 211.49 70.42 ± 12.80 450.16 ± 161.82 28.35 ± 12.75 207.01 ± 186.37 95.36 ± 4.36 611.66 ± 327.88 65.3 ± 13.68 288.07 ± 118.46 29.66 ± 11.17 143.33 ± 95.13 38.78 ± 13.86 174.12 ± 92.71 1.71 ± 0.92
 Middle 1274.92 ± 452.69 193.84 ± 103.67 261.69 ± 203.82 745.08 ± 269.35 449.80 ± 219.66 73.16 ± 12.48 542.60 ± 217.98 25.27 ± 12.33 190.65 ± 122.15 92.76 ± 8.42 689.79 ± 256.35 57.03 ± 17.84 238.78 ± 102.11 37.58 ± 13.74 178.92 ± 133.65 32.53 ± 13.13 143.6 ± 86.67 1.90 ± 0.85
 Elder 1239.03 ± 460.52 178.59 ± 94.77 279.02 ± 225.75 757.07 ± 323.13 427.96 ± 208.82 74.29 ± 13.17 550.16 ± 227.77 22.84 ± 11.88 175.23 ± 121.60 91.73 ± 9.73 673.78 ± 272.92 53.56 ± 16.83 215.74 ± 104.94 40.25 ± 14.32 177.39 ± 130.65 28.80 ± 12.90 125.61 ± 100.69 2.06 ± 1.11
 P 0.688 0.550 0.446 0.152 0.425 0.275 0.077 0.055 0.338 0.121 0.169 0.006 0.003 0.002 0.521  < 0.001 0.001 0.123
Allergic history
 Antibiotic 1247.95 ± 325.87 179.33 ± 111.83 213.09 ± 121.54 714.35 ± 243.96 447.59 ± 190.59 75.65 ± 11.83 533.42 ± 183.06 21.00 ± 11.73 159.85 ± 119.09 91.83 ± 10.97 640.66 ± 273.15 60.33 ± 17.27 250.68 ± 90.57 35.95 ± 15.01 169.99 ± 135.4 33.17 ± 16.32 146.63 ± 107.45 1.89 ± 1.07
 Other 1397.30 ± 255.23 286.59 ± 60.68 245.97 ± 195.28 834.23 ± 210.96 475.6 ± 76.96 69.81 ± 9.10 590.88 ± 217.92 28.21 ± 10.03 226.12 ± 79.85 94.97 ± 2.95 795.26 ± 213.46 66.68 ± 9.31 320.55 ± 85.93 26.80 ± 5.40 126.96 ± 30.38 28.72 ± 11.96 137.68 ± 68.03 1.76 ± 0.36
 No 1245.96 ± 478.24 184.37 ± 96.29 260.92 ± 195.87 752.53 ± 319.46 433.62 ± 209.25 73.03 ± 13.24 540.24 ± 231.06 24.81 ± 12.38 188.6 ± 131.45 92.42 ± 8.83 683.06 ± 276.73 55.43 ± 17.11 227.6 ± 109.03 38.18 ± 13.92 171.09 ± 120.46 30.92 ± 13.24 133.85 ± 91.74 1.99 ± 1.01
 P 0.431 0.018 0.568 0.527 0.417 0.323 0.780 0.138 0.158 0.975 0.367 0.107 0.026 0.033 0.747 0.807 0.751 0.723
Surgery
 Yes 1285.26 ± 471.23 182.04 ± 95.87 269.73 ± 203.91 749.71 ± 321.18 461.57 ± 221.21 73.04 ± 14.00 531.97 ± 210.35 24.12 ± 12.70 185.17 ± 136.17 91.56 ± 9.34 671.28 ± 269.38 53.28 ± 17.43 230.14 ± 108.07 39.62 ± 14.65 190.36 ± 136.55 32.75 ± 13.90 151.70 ± 106.33 1.88 ± 0.98
 No 1231.11 ± 436.88 187.04 ± 98.35 245.17 ± 178.12 752.79 ± 294.67 421.08 ± 203.97 73.73 ± 11.76 553.58 ± 238.93 24.55 ± 11.76 186.15 ± 121.17 93.30 ± 8.54 687.78 ± 284.41 58.65 ± 17.11 234.36 ± 109.49 36.27 ± 13.26 158.90 ± 122.38 28.62 ± 11.73 118.04 ± 72.55 2.09 ± 1.07
 P 0.428 0.866 0.272 0.708 0.098 0.898 0.456 0.552 0.653 0.141 0.543 0.008 0.593 0.072 0.019 0.014 0.013 0.039
History of diseases
 No 1301.63 ± 413.78 187.44 ± 97.57 294.99 ± 271.76 752.48 ± 256.8 462.89 ± 233.94 73.22 ± 12.76 545.68 ± 193.04 25.08 ± 12.72 193.87 ± 139.93 91.08 ± 8.93 686.59 ± 249.44 55.50 ± 16.87 238.56 ± 106.90 38.49 ± 14.95 185.52 ± 142.82 33.55 ± 12.46 154.74 ± 96.26 2.00 ± 1.07
 Yes 1234.46 ± 470.19 183.60 ± 96.63 252.92 ± 188.98 747.32 ± 322.23 431.22 ± 204.75 73.54 ± 13.19 539.69 ± 233.47 23.99 ± 12.24 181.21 ± 124.61 93.01 ± 8.92 674.79 ± 283.1 56.31 ± 17.74 229.26 ± 108.56 38.13 ± 14.15 170.82 ± 125.08 30.13 ± 13.64 128.74 ± 90.76 1.98 ± 1.00
 P 0.318 0.670 0.196 0.600 0.453 0.808 0.566 0.601 0.468 0.043 0.629 0.644 0.541 0.741 0.455 0.012 0.022 0.864
Smoking history
 No 1249.36 ± 463.71 194.16 ± 98.74 240.88 ± 167.3 744.68 ± 317.46 436.33 ± 214.38 72.58 ± 13.3 528.07 ± 217.8 25.19 ± 12.45 191.36 ± 137.93 92.66 ± 8.77 672.86 ± 272.05 55.95 ± 17.32 228.75 ± 105.67 37.11 ± 13.89 168.54 ± 130.16 31.02 ± 12.18 134.95 ± 87.04 1.95 ± 0.97
 Yes 1395.45 ± 460.14 204.81 ± 106.52 267.17 ± 174.27 854.83 ± 322.1 471.48 ± 185.99 74.52 ± 11.83 541.63 ± 201.09 22.63 ± 11.47 167.39 ± 103.98 91.2 ± 9.42 653.13 ± 253.27 54.51 ± 15.95 228.12 ± 105.94 39.96 ± 14.98 185.87 ± 139.02 30.78 ± 14.5 138.87 ± 111.4 2.01 ± 0.86
 Cessation 1220.78 ± 388.34 151.82 ± 90.12 329.4 ± 260.19 728.75 ± 246.2 441.08 ± 209.86 75.07 ± 12.07 634.99 ± 265.64 23.24 ± 12.14 204.1 ± 122.55 93.16 ± 9.43 791.84 ± 313.28 58.35 ± 18.73 264.2 ± 115.09 37.68 ± 13.03 185.99 ± 109.14 26.63 ± 10.94 122.51 ± 78.83 2.05 ± 1.17
 P 0.124 0.007 0.170 0.086 0.343 0.527 0.062 0.382 0.377 0.136 0.088 0.638 0.200 0.437 0.179 0.133 0.767 0.882
Drinking history
 No 1261.05 ± 464.45 194.59 ± 103.37 248.44 ± 175.23 752.68 ± 323.32 451.27 ± 223.03 73.12 ± 13.24 541.44 ± 234.83 24.47 ± 12.37 185.61 ± 130.73 92.61 ± 9.08 678.53 ± 287.05 55.91 ± 17.39 237.64 ± 113.07 38.02 ± 14.7 180.04 ± 139.59 31.42 ± 13.64 140.47 ± 95.31 1.92 ± 0.98
 Yes 1261.86 ± 459.97 160.90 ± 77.59 303.90 ± 251.43 762.52 ± 255.07 409.57 ± 187.12 77.26 ± 14.85 528.60 ± 176.76 20.22 ± 14.72 151.40 ± 132.36 91.04 ± 6.82 636.21 ± 206.03 55.11 ± 12.18 231.52 ± 67.87 37.27 ± 9.00 154.28 ± 35.43 29.04 ± 10.35 120.53 ± 43.69 2.22 ± 1.13
 Abstinence 1193.52 ± 242.43 124.90 ± 67.65 219.10 ± 116.42 698.20 ± 219.11 426.90 ± 104.67 72.98 ± 12.51 547.67 ± 185.77 25.24 ± 12.38 200.74 ± 131.11 91.99 ± 8.7 699.64 ± 244.28 55.65 ± 17.8 212.66 ± 90.33 38.86 ± 13.23 162.34 ± 104.68 29.20 ± 12.78 122.15 ± 94.93 1.76 ± 0.80
 P 0.902 0.020 0.651 0.589 0.542 0.454 0.738 0.364 0.312 0.291 0.626 0.937 0.438 0.676 0.925 0.458 0.177 0.152
ECOG PS
 0 1249.01 ± 470.92 189.54 ± 97.22 256.76 ± 188.20 755.79 ± 314.37 433.64 ± 208.84 73.07 ± 13.01 542.99 ± 227.84 24.55 ± 12.23 188.23 ± 130.96 92.41 ± 9.11 687.18 ± 275.96 56.88 ± 17.01 233.15 ± 108.53 37.34 ± 14.28 168.51 ± 125.77 30.31 ± 12.37 129.85 ± 84.49 2.00 ± 1.00
 1 1269.76 ± 376.02 157.46 ± 88.47 314.7 ± 345.09 723.17 ± 241.1 463.12 ± 259.22 74.22 ± 12.16 531.84 ± 187.04 24.57 ± 11.79 181.96 ± 110.51 93.97 ± 5.72 638.85 ± 261.14 51.87 ± 18.1 214.82 ± 99.14 40.64 ± 13.28 194.72 ± 158.1 33.24 ± 15.22 161.51 ± 137.98 2.02 ± 1.15
 2 1202.74 ± 242.49 181.56 ± 165.45 390.44 ± 282.96 632.00 ± 218.54 422.78 ± 129.95 77.45 ± 16.10 462.00 ± 79.90 19.88 ± 15.63 153.11 ± 176.08 88.14 ± 14.21 572.20 ± 257.73 49.58 ± 18.76 199.06 ± 87.64 44.74 ± 13.11 197.60 ± 117.35 38.93 ± 18.6 177.33 ± 133.09 1.58 ± 0.57
 3 1268 ± 534.57 257 ± 96.17 312 ± 91.92 633.5 ± 297.69 589 ± 260.22 90.59 ± 3.75 579.5 ± 293.45 7.69 ± 4.51 42.00 ± 5.66 96.05 ± 0.49 608 ± 282.84 52.1 ± 10.04 294 ± 76.37 45.05 ± 13.51 283 ± 196.58 20.95 ± 7.42 133.5 ± 98.29 1.07 ± 0.04
 P 0.966 0.093 0.267 0.541 0.776 0.138 0.779 0.115 0.075 0.881 0.617 0.264 0.395 0.104 0.427 0.280 0.705 0.188
Histology
 LAC 1239.83 ± 463.04 186.72 ± 98.1 262.97 ± 207.77 741.78 ± 309.04 432.47 ± 215.11 73.16 ± 12.97 533.68 ± 223.57 24.59 ± 12.26 185.23 ± 129.68 92.36 ± 9.22 669.8 ± 275.26 55.87 ± 17.38 226.45 ± 107.45 38.19 ± 14.1 171.93 ± 129.37 31.34 ± 12.95 135.01 ± 90.69 2.00 ± 1.03
 LSC 1355.94 ± 346.96 161.44 ± 98.52 308.93 ± 241.53 766.33 ± 231.97 508.07 ± 182.7 78.18 ± 10.83 593.22 ± 184.44 19.62 ± 10.23 157.22 ± 97.15 92.73 ± 5.56 711.58 ± 223.72 54.83 ± 16.04 266.91 ± 91.29 40.11 ± 14.84 208.43 ± 128.57 28.67 ± 16.78 153.82 ± 138.5 1.69 ± 0.73
 LASC 1562.36 298.00 909.00 1060.00 459.00 54.34 576.00 44.72 474.00 100.00 1060 75.90 348.38 38.70 177.63 12.60 57.83 2.31
 P 0.189 0.111 0.206 0.299 0.071 0.034 0.189 0.034 0.178 0.132 0.185 0.430 0.031 0.908 0.121 0.072 0.492 0.336
Tumor stage
 T1 1287.03 ± 461.46 199.48 ± 97.84 251.40 ± 185.00 771.03 ± 306.11 452.45 ± 209.34 72.5 ± 12.94 548.64 ± 209.38 25.08 ± 12.12 195.9 ± 134.25 92.84 ± 8.03 700.98 ± 270.52 55.8 ± 16.78 241.11 ± 109.81 37.68 ± 13.55 175.94 ± 127.54 29.33 ± 11.65 132.03 ± 81.94 1.93 ± 0.92
 T2 1132.15 ± 467.27 151.1 ± 86.35 237.71 ± 174.92 651.4 ± 307.11 393.92 ± 221.18 75.83 ± 11.66 486.99 ± 232.91 22.24 ± 11.46 151.16 ± 110.95 91.5 ± 9.2 580.82 ± 302.24 57.08 ± 17.45 206.53 ± 106.04 38.86 ± 14.46 161.27 ± 128.67 32.53 ± 14.45 128.38 ± 103.22 2.00 ± 1.03
 T3 1249.3 ± 474.78 138.25 ± 67.27 306.25 ± 230.88 766.37 ± 303.9 410.42 ± 206.36 78.33 ± 10.56 598.67 ± 258.33 20.01 ± 10.82 155.53 ± 92.08 93.41 ± 5.16 715.91 ± 297.6 59.04 ± 16.63 226.78 ± 116.11 36.41 ± 13.99 164.79 ± 133.54 29.23 ± 13.01 120.75 ± 104.33 2.17 ± 0.80
 T4 1226.94 ± 342.63 167.96 ± 107.62 349.64 ± 223.54 725.14 ± 207.8 427 ± 229.09 75.31 ± 12.43 541.55 ± 176.54 22.98 ± 12.26 170.36 ± 102.28 92.89 ± 9.07 670.33 ± 195.47 53.65 ± 21.62 199.97 ± 80.2 40.49 ± 14.87 173.75 ± 117.93 35.83 ± 15.59 163.63 ± 144.56 2.17 ± 1.28
P 0.085 0.002 0.093 0.033 0.257 0.142 0.100 0.188 0.129 0.923 0.016 0.702 0.088 0.612 0.669 0.191 0.430 0.532
Lymph nodes metastases
 N0 1273.8 ± 446.29 195.1 ± 97.38 251.71 ± 181.65 768.04 ± 303.92 441.54 ± 198.47 72.86 ± 12.89 549.78 ± 211.12 24.95 ± 12.09 193.59 ± 131.95 93.11 ± 7.56 697.13 ± 272.62 57.11 ± 16.46 241.44 ± 109.47 37.11 ± 13.59 168.68 ± 117.45 29.45 ± 11.66 128.97 ± 77.58 1.96 ± 0.93
 N1 1400.43 ± 633.16 212.75 ± 108.69 282.25 ± 206.57 779.17 ± 316.94 472.25 ± 267.66 76.96 ± 13.38 583.42 ± 222.68 21.28 ± 13.32 179.58 ± 140.93 90.83 ± 11.91 698.56 ± 266.3 51.27 ± 20.07 215.31 ± 91.73 40.2 ± 12.8 197.74 ± 138.02 33.98 ± 19.63 155.51 ± 121.06 1.91 ± 0.86
 N2 1241.51 ± 463.87 158.63 ± 85.08 254.33 ± 146.18 686.63 ± 320.14 477.71 ± 276.70 75.19 ± 11.33 511.32 ± 248.97 21.63 ± 10.81 154.41 ± 107.8 90.83 ± 9.74 630.08 ± 318.86 50.32 ± 17.87 217.47 ± 116.06 41.15 ± 14.88 213.69 ± 183.42 30.12 ± 14.02 149.22 ± 131.7 1.84 ± 1.01
 N3 1068.74 ± 429.88 136.71 ± 91.75 271.63 ± 179.01 650.58 ± 231.06 360.04 ± 211.56 74.49 ± 13.07 478.46 ± 182.73 23.75 ± 12.99 161.13 ± 110.39 91.98 ± 9.08 595.73 ± 212.16 56.8 ± 20.42 180.36 ± 78.89 40.46 ± 14.02 147.53 ± 108.87 36.11 ± 13.48 140.09 ± 133.64 2.23 ± 1.22
 P 0.248 0.008 0.729 0.127 0.115 0.545 0.227 0.385 0.266 0.556 0.152 0.202 0.030 0.217 0.492 0.114 0.936 0.696
Distant metastases
 M0 1281.78 ± 462.6 193.06 ± 97.13 254.16 ± 190.11 763.80 ± 308.98 448.96 ± 214.58 73.1 ± 12.83 548.94 ± 218.46 24.6 ± 12.05 190.51 ± 131 93.00 ± 7.89 694.48 ± 279.02 56.38 ± 16.78 239.97 ± 110.12 37.69 ± 13.94 175.8 ± 131.19 29.61 ± 12.1 132.35 ± 87.17 1.94 ± 0.91
 M1 1141.48 ± 396.68 145.72 ± 90.52 330.67 ± 302.36 671.32 ± 279.37 397.7 ± 198.3 75.95 ± 12.17 507.09 ± 242.88 21.89 ± 12.04 149.67 ± 101.18 88.73 ± 13.12 583.34 ± 219.81 52.2 ± 18.79 186.2 ± 81.8 40.76 ± 12.99 168.68 ± 109.18 35.05 ± 15.59 146.02 ± 121.53 2.12 ± 1.40
 P 0.099 0.001 0.049 0.040 0.121 0.278 0.103 0.208 0.049 0.040 0.015 0.099 0.001 0.065 0.827 0.053 0.908 0.926
  1. Bold represents p <0.05, the difference was statistically significant
  2. LAC lung adenocarcinoma, LSC squamous carcinoma, LASC lung adenosquamous carcinoma