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Table 4 Relationship between inflammatory cells levels and clinicopathologic characteristics

From: Circulating activated immune cells as a potential blood biomarkers of non-small cell lung cancer occurrence and progression

  WBC (cells/10^12ul) Lymphocytes (cells/10^12ul) Monocytes (cells/ul) Neutrophils (cells/ul) Eosnophils (cells/ul) Basophils (cells/ul) RBC (cells/ul) Hemoglobins (cells/ul) Blood platelets (cells/ul) MLR NLR ELR BLR RLR HLR PLR
Gender
 Male 7.10 ± 2.99 1.71 ± 0.57 0.44 ± 0.18 4.79 ± 2.98 0.15 ± 0.15 0.03 ± 0.02 4.68 ± 0.61 144.94 ± 13.64 223.76 ± 63.84 0.28 ± 0.15 3.18 ± 2.6 0.13 ± 0.43 0.03 ± 0.13 3.07 ± 1.38 96.81 ± 45.58 146.20 ± 78.14
 Female 6.42 ± 2.79 1.76 ± 0.62 0.33 ± 0.14 4.14 ± 2.81 0.12 ± 0.13 0.03 ± 0.02 4.37 ± 0.51 132.6 ± 12.14 231.43 ± 62.2 0.21 ± 0.15 2.82 ± 2.86 0.07 ± 0.08 0.02 ± 0.01 2.82 ± 1.21 85.59 ± 36.44 146.73 ± 63.55
 P 0.005 0.693  < 0.001 0.001 0.006 0.574  < 0.001  < 0.001 0.217  < 0.001 0.001 0.002 0.649 0.054 0.007 0.570
Age
 Yong 6.39 ± 2.91 1.79 ± 0.84 0.37 ± 0.14 3.99 ± 2.2 0.1 ± 0.09 0.02 ± 0.01 4.39 ± 0.59 130.24 ± 21.42 231.48 ± 73.2 0.23 ± 0.12 2.81 ± 3.3 0.07 ± 0.07 0.01 ± 0.01 2.89 ± 1.27 85.83 ± 41.37 150.75 ± 76.23
 Middle 7.06 ± 3.14 1.75 ± 0.58 0.38 ± 0.17 4.77 ± 3.26 0.14 ± 0.18 0.03 ± 0.02 4.6 ± 0.45 140.82 ± 13.48 235.03 ± 58.01 0.24 ± 0.15 3.29 ± 3.21 0.12 ± 0.47 0.03 ± 0.15 2.96 ± 1.36 92.60 ± 46.07 153.95 ± 87.09
 Elder 6.55 ± 2.71 1.72 ± 0.57 0.38 ± 0.16 4.27 ± 2.71 0.13 ± 0.11 0.03 ± 0.01 4.47 ± 0.65 137.71 ± 12.93 222.26 ± 64.53 0.25 ± 0.15 2.81 ± 2.26 0.09 ± 0.09 0.02 ± 0.01 2.93 ± 1.25 90.19 ± 37.56 140.53 ± 54.57
 P 0.204 0.868 0.948 0.243 0.198 0.385 0.029 0.010 0.148 0.766 0.401 0.157 0.278 0.998 0.718 0.693
Allergic history
 Antibiotic 6.48 ± 3.01 1.68 ± 0.44 0.36 ± 0.15 4.29 ± 2.91 0.15 ± 0.22 0.03 ± 0.02 4.39 ± 0.93 137.84 ± 13.4 217.74 ± 50.39 0.22 ± 0.09 2.64 ± 1.77 0.09 ± 0.12 0.02 ± 0.01 2.81 ± 0.95 87.96 ± 25.82 138.27 ± 54.36
 Other 8.45 ± 5.03 1.94 ± 0.19 0.44 ± 0.27 6.01 ± 5.12 0.13 ± 0.12 0.02 ± 0.01 4.51 ± 0.34 132.83 ± 18.74 196.17 ± 47.63 0.23 ± 0.13 3.06 ± 2.56 0.06 ± 0.06 0.01 ± 0.01 2.33 ± 0.19 68.34 ± 7.28 101.13 ± 24.55
 No 6.75 ± 2.95 1.72 ± 0.63 0.38 ± 0.17 4.46 ± 2.97 0.13 ± 0.13 0.03 ± 0.02 4.54 ± 0.46 138.65 ± 14.4 228.96 ± 64.09 0.25 ± 0.16 3.11 ± 2.98 0.08 ± 0.1 0.02 ± 0.01 3.02 ± 1.38 93.26 ± 44.67 150.07 ± 74.34
 P 0.413 0.315 0.750 0.553 0.782 0.730 0.891 0.665 0.373 0.777 0.957 0.893 0.409 0.363 0.214 0.096
Surgery history
 Yes 6.97 ± 3.2 1.75 ± 0.59 0.4 ± 0.18 4.65 ± 3.25 0.14 ± 0.15 0.03 ± 0.02 4.57 ± 0.6 140.82 ± 15.29 229.88 ± 62.68 0.25 ± 0.16 3.13 ± 3 0.09 ± 0.1 0.02 ± 0.01 2.99 ± 1.43 91.69 ± 43.48 147.11 ± 72.87
 No 6.53 ± 2.72 1.72 ± 0.61 0.37 ± 0.15 4.26 ± 2.7 0.12 ± 0.14 0.03 ± 0.02 4.46 ± 0.43 135.53 ± 12.88 223.73 ± 62.25 0.24 ± 0.14 2.88 ± 2.61 0.08 ± 0.09 0.02 ± 0.01 2.94 ± 1.19 89.57 ± 36.65 142.06 ± 53.96
 P 0.273 0.422 0.305 0.190 0.113 0.640 0.016 0.001 0.392 0.248 0.290 0.125 0.802 0.961 0.932 0.724
History of diseases
 Yes 6.78 ± 3.04 1.84 ± 0.66 0.38 ± 0.16 4.39 ± 2.96 0.13 ± 0.16 0.03 ± 0.02 4.59 ± 0.44 139.17 ± 13.08 224.72 ± 59.42 0.23 ± 0.13 2.74 ± 2.48 0.08 ± 0.1 0.02 ± 0.01 2.77 ± 0.95 84.33 ± 29.28 134.86 ± 55.33
 No 6.73 ± 2.95 1.69 ± 0.59 0.38 ± 0.17 4.48 ± 2.99 0.13 ± 0.14 0.03 ± 0.02 4.5 ± 0.56 137.9 ± 14.86 227.4 ± 64.64 0.25 ± 0.16 3.13 ± 2.93 0.09 ± 0.1 0.02 ± 0.01 3.03 ± 1.41 93.82 ± 45.67 151.01 ± 76.92
 P 0.624 0.158 0.909 0.276 0.558 0.640 0.484 0.732 0.734 0.128 0.058 0.315 0.124 0.366 0.354 0.164
Smoking history
 No 6.45 ± 2.74 1.72 ± 0.61 0.35 ± 0.14 4.22 ± 2.75 0.13 ± 0.14 0.03 ± 0.02 4.48 ± 0.41 135.79 ± 13.4 226.4 ± 61.11 0.23 ± 0.16 2.96 ± 2.92 0.08 ± 0.1 0.02 ± 0.01 2.98 ± 1.27 90.32 ± 39.30 146.68 ± 62.1
 Yes 8.29 ± 3.92 1.89 ± 0.57 0.47 ± 0.24 5.87 ± 4.01 0.13 ± 0.09 0.03 ± 0.02 4.67 ± 0.54 144.21 ± 15.72 238.48 ± 69.31 0.27 ± 0.14 3.53 ± 3.42 0.22 ± 0.86 0.06 ± 0.27 2.86 ± 1.72 88.19 ± 52.90 143.81 ± 87.75
 Cessation 7.1 ± 2.83 1.75 ± 0.53 0.44 ± 0.16 4.6 ± 2.87 0.15 ± 0.12 0.03 ± 0.02 4.56 ± 0.78 143.95 ± 13.42 227.61 ± 65.45 0.27 ± 0.16 2.85 ± 1.69 0.09 ± 0.07 0.02 ± 0.01 2.88 ± 1.10 91.01 ± 32.92 139.32 ± 50.79
 P 0.001 0.121  < 0.001 0.002 0.098 0.145 0.004  < 0.001 0.810  < 0.001 0.039 0.145 0.493 0.291 0.436 0.544
Drinking history
 No 6.61 ± 2.96 1.74 ± 0.62 0.36 ± 0.16 4.35 ± 2.96 0.13 ± 0.13 0.03 ± 0.02 4.49 ± 0.52 136.56 ± 13.76 226.67 ± 65.26 0.24 ± 0.16 2.96 ± 2.83 0.08 ± 0.09 0.02 ± 0.01 2.95 ± 1.30 90.67 ± 42.41 146.45 ± 71.94
 Yes 7.5 ± 3.11 1.76 ± 0.58 0.45 ± 0.19 5.06 ± 3.21 0.13 ± 0.14 0.03 ± 0.02 4.58 ± 0.54 142.33 ± 16.02 237.23 ± 56.72 0.28 ± 0.14 3.37 ± 2.99 0.17 ± 0.66 0.04 ± 0.21 2.93 ± 1.43 90.94 ± 43.80 150.91 ± 75.76
 Abstinence 5.88 ± 0.78 1.55 ± 0.37 0.36 ± 0.07 3.71 ± 0.67 0.15 ± 0.08 0.03 ± 0.01 4.64 ± 0.3 147 ± 8.94 202.7 ± 44.87 0.24 ± 0.05 2.52 ± 0.83 0.11 ± 0.07 0.02 ± 0.01 3.14 ± 0.75 99.63 ± 23.28 137.85 ± 43.66
 P 0.026 0.608 0.002 0.066 0.399 0.747 0.267 0.002 0.224 0.003 0.062 0.227 0.511 0.391 0.208 0.860
ECOG
 0 6.63 ± 2.95 1.73 ± 0.61 0.37 ± 0.16 4.35 ± 2.93 0.13 ± 0.13 0.03 ± 0.02 4.52 ± 0.6 138.95 ± 13.76 223.09 ± 56.85 0.24 ± 0.15 2.95 ± 2.77 0.1 ± 0.33 0.02 ± 0.1 2.97 ± 1.35 9.20 ± 43.06 144.96 ± 71.59
 1 7.69 ± 3.02 1.76 ± 0.58 0.44 ± 0.21 5.28 ± 3.31 0.15 ± 0.21 0.03 ± 0.02 4.52 ± 0.54 135.51 ± 17.79 243.46 ± 85.24 0.28 ± 0.16 3.67 ± 3.27 0.09 ± 0.12 0.02 ± 0.01 2.85 ± 1.09 85.63 ± 34.63 153.77 ± 74.35
 2 7.14 ± 2.05 1.78 ± 0.56 0.41 ± 0.09 4.78 ± 1.57 0.12 ± 0.03 0.03 ± 0.01 4.41 ± 0.47 128.44 ± 15.29 299.33 ± 81.73 0.25 ± 0.06 2.79 ± 0.89 0.07 ± 0.03 0.02 ± 0 2.7 ± 0.91 78.28 ± 25.33 177.7 ± 58.41
 3 7.52 ± 1.23 1.85 ± 0.54 0.39 ± 0.09 4.96 ± 1.5 0.27 ± 0.17 0.05 ± 0.02 4.79 ± 0.2 145.5 ± 6.36 286.5 ± 30.41 0.23 ± 0.11 2.92 ± 1.66 0.17 ± 0.14 0.03 ± 0.02 2.72 ± 0.90 82.63 ± 27.44 159.19 ± 29.81
 P 0.008 0.974 0.069 0.027 0.426 0.146 0.448 0.116 0.013 0.207 0.146 0.670 0.357 0.949 0.714 0.206
Histology
 LAC 6.65 ± 2.88 1.72 ± 0.61 0.37 ± 0.15 4.39 ± 2.91 0.13 ± 0.14 0.03 ± 0.02 4.52 ± 0.59 138.32 ± 14.25 227.25 ± 63.48 0.24 ± 0.15 3.02 ± 2.84 0.08 ± 0.1 0.02 ± 0.01 2.98 ± 1.33 92.06 ± 42.41 147.99 ± 72.41
 LSC 7.5 ± 2.99 1.85 ± 0.48 0.5 ± 0.24 4.9 ± 2.89 0.17 ± 0.12 0.03 ± 0.01 4.45 ± 0.42 136.85 ± 13.66 234.58 ± 59.29 0.28 ± 0.14 2.68 ± 1.43 0.27 ± 0.95 0.07 ± 0.3 2.44 ± 0.84 78.06 ± 22.37 132.90 ± 44.88
 LASC 10.30 2.78 0.85 6.29 0.12 0.05 5.17 163.00 234.00 0.31 2.26 0.04 0.02 1.86 58.63 84.17
 P 0.076 0.089 0.002 0.153 0.078 0.223 0.173 0.233 0.864 0.073 0.787 0.148 0.918 0.090 0.106 0.281
Tumor stage
 T1 6.73 ± 3.1 1.78 ± 0.6 0.37 ± 0.16 4.46 ± 3.18 0.12 ± 0.11 0.03 ± 0.02 4.54 ± 0.43 139.19 ± 12.52 220.86 ± 50.95 0.23 ± 0.15 2.93 ± 2.89 0.07 ± 0.06 0.02 ± 0.01 2.87 ± 1.16 87.98 ± 35.62 136.47 ± 54.37
 T2 6.07 ± 2.75 1.5 ± 0.61 0.37 ± 0.17 3.89 ± 2.51 0.15 ± 0.19 0.03 ± 0.02 4.39 ± 0.83 136.91 ± 16.88 212.38 ± 72.67 0.28 ± 0.17 2.9 ± 2.14 0.12 ± 0.16 0.02 ± 0.01 3.45 ± 1.65 106.71 ± 49.24 158.63 ± 68.37
 T3 7.6 ± 2.69 1.71 ± 0.6 0.5 ± 0.25 5.22 ± 2.49 0.13 ± 0.08 0.04 ± 0.02 4.58 ± 0.59 137.56 ± 17.66 275.56 ± 97.81 0.32 ± 0.17 3.86 ± 4.25 0.38 ± 1.23 0.12 ± 0.39 3.18 ± 2.23 96.30 ± 69.57 184.22 ± 116.91
 T4 7.48 ± 1.63 1.76 ± 0.4 0.44 ± 0.14 4.77 ± 1.77 0.25 ± 0.25 0.04 ± 0.02 4.61 ± 0.46 136.77 ± 16.46 264.46 ± 62.89 0.27 ± 0.1 3.03 ± 1.15 0.15 ± 0.15 0.03 ± 0.02 2.77 ± 0.72 81.86 ± 21.57 160.05 ± 60.92
 P 0.001 0.012 0.001 0.005 0.010  < 0.001 0.793 0.763  < 0.001 0.001 0.009 0.004 0.001 0.079 0.055 0.054
Lymph nodes metastasesLymph nodes metastases
 N0 6.66 ± 3.19 1.76 ± 0.6 0.37 ± 0.16 4.42 ± 3.2 0.12 ± 0.11 0.03 ± 0.02 4.52 ± 0.43 138.51 ± 12.6 221.37 ± 54.06 0.23 ± 0.14 2.88 ± 2.8 0.07 ± 0.06 0.02 ± 0.01 2.89 ± 1.17 88.64 ± 36.07 137.98 ± 54.92
 N1 6.37 ± 1.86 1.91 ± 0.78 0.38 ± 0.17 3.8 ± 1.4 0.19 ± 0.31 0.04 ± 0.03 4.55 ± 0.47 136.08 ± 20.46 242.17 ± 53.11 0.21 ± 0.08 2.29 ± 1.24 0.11 ± 0.18 0.02 ± 0.02 2.72 ± 1.01 80.3 ± 30.07 146.62 ± 65.04
 N2 6.92 ± 2.37 1.61 ± 0.56 0.42 ± 0.21 4.56 ± 2.33 0.16 ± 0.2 0.03 ± 0.02 4.58 ± 0.47 137.76 ± 15.24 233.91 ± 87.64 0.29 ± 0.18 3.23 ± 2.12 0.1 ± 0.14 0.02 ± 0.01 3.23 ± 1.36 97.25 ± 42.04 158.95 ± 71.24
 N3 7.18 ± 1.85 1.52 ± 0.46 0.45 ± 0.14 4.67 ± 2.21 0.19 ± 0.17 0.04 ± 0.02 4.74 ± 0.46 143.75 ± 17.54 246.29 ± 69.55 0.34 ± 0.19 4.05 ± 3.96 0.35 ± 1 0.09 ± 0.32 3.61 ± 2.06 109.83 ± 64.92 181.93 ± 98.02
 P 0.020 0.238 0.010 0.096 0.108 0.041 0.275 0.447 0.284  < 0.001 0.007 0.012 0.001 0.093 0.124 0.048
Distant metastases
 M0 6.68 ± 3.08 1.76 ± 0.61 0.37 ± 0.17 4.4 ± 3.1 0.12 ± 0.12 0.03 ± 0.02 4.52 ± 0.42 138.12 ± 13.03 221.55 ± 54.66 0.24 ± 0.15 2.89 ± 2.72 0.07 ± 0.08 0.02 ± 0.01 2.91 ± 1.19 88.82 ± 36.55 139.34 ± 56.81
 M1 7.13 ± 2.1 1.65 ± 0.53 0.42 ± 0.15 4.7 ± 2.09 0.2 ± 0.21 0.04 ± 0.02 4.69 ± 0.56 140.78 ± 18.37 255.59 ± 88.44 0.29 ± 0.17 3.49 ± 3.07 0.24 ± 0.73 0.06 ± 0.23 3.26 ± 1.73 98.76 ± 54.84 170.25 ± 86.91
 P 0.003 0.415 0.011 0.004 0.003 0.001 0.034 0.183 0.013 0.003 0.002  < 0.001  < 0.001 0.233 0.352 0.011
  1. Bold represents p <0.05, the difference was statistically significant
  2. LAC lung adenocarcinoma, LSC squamous carcinoma, LASC lung adenosquamous carcinoma