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Table 2 Oxygenation parameters

From: Hyperoxaemia and hypoxaemia are associated with harm in patients with ARDS

Parameter

Overall

N = 202

Non-Survivors

N = 63

Survivors

N = 139

p-value

Highest PaO2

(kPa) {mmHg}

17.40 [14.8, 21.9]

{130.5 [111.0, 164.3]}

16.5 [14.3, 21.8]

{123.8 [107.3, 163.5]}

18.2 [15.0, 21.8]

{136.5 [112.5, 163.5]}

0.22

Highest FiO2 (%)

0.7 [0.5, 0.8]

0.7 [0.6, 0.9]

0.7 [0.5, 0.8]

0.17

Highest P/F ratio

(kPa) {mmHg}

41.0 [32.7, 48.6]

{307.5 {245.3, 364.5]}

38.2 [26.4, 44.6]

{286.5 [198.0, 334.5]}

41.7 [35.1, 49.5]

{312.8 [263.3, 371.3]}

0.004

Average time-weighted PaO2 (kPa) {mmHg}

    

First 24 h of ARDS

11.5 [10.4, 13.1]

{86.3 [78.0, 98.3]}

11.4 [10.1, 12.9]

{85.5 [75.8, 96.8]}

11.6 [10.5, 13.1]

{87.0 [78.8, 98.3]}

0.37

First 7 days of ARDS

11.8 [10.7, 12.6]

{88.5 [80.3, 94.5]}

11.3 [10.2, 12.5]

{84.8 [76.5, 93.8]}

11.9 [10.9, 12.6]

{89.3 [81.8, 94.5]}

0.08

Number of hyperoxaemia episodes (First 7 days of ARDS)

3.0 [1.0, 6.0]

2.0 [0.5, 4.0]

3.0 [1.0, 6.0]

0.04

Any hyperoxaemia episode–N (%)

166 (82)

47 (75)

119 (86)

0.09

Ever exposed to excess oxygen–N (%)

111 (55)

36 (57)

75 (54)

0.79

Excess oxygen exposure

    

First 24 h of ARDS

0.0 [0.0, 0.2]

0.0 [0.0, 0.2]

0.0 [0.0, 0.1]

0.75

First 7 days of ARDS

0.1 [0.0, 0.2]

0.1 [0.0, 0.2]

0.1 [0.0, 0.3]

0.84

  1. Data are presented as median [IQR] unless otherwise stated
  2. Values of oxygenation are presented in kPa, and the corresponding values in mmHg is presented in italics
  3. Average time-weighted PaO2 was obtained by calculating the value between consecutive time points prior to multiplying this value by the period of time between these points. The sum of these time-weighted values was then divided by the total time of mechanical ventilation within the timepoints of interest. Hyperoxaemia was defined as a PaO2 > 14 kPa (105 mmHg). Excess oxygen exposure was defined as any FiO2 value above an FiO2 > 0.5 in patients with a PaO2 > 10.7 kPa (80.3 mmHg), and was calculated at 24-h intervals with a cumulative value obtained
  4. PaO2, partial pressure of arterial oxygen; FiO2, Fraction of inspired oxygen; P/F ratio, partial pressure of arterial oxygen to fraction of inspired oxygen ratio