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Table 3 Predictors of malignancy

From: Clinical-radiological predictive model in differential diagnosis of small (≤ 20 mm) solitary pulmonary nodules

Variables Univariate analysis Multivariate analysis
Hazard ratio 95% CI P value Hazard ratio 95% CI P value
Age 1.120 1.085–1.157  < 0.001 1.138 1.092–1.186  < 0.001
Size 1.177 1.107–1.252  < 0.001 1.086 0.995–1.181 0.065
Lobulation 2.493 1.456–4.267 0.001 2.143 0.980–4.689 0.056
Spiculation 3.333 1.924–5.776  < 0.001 0.739 0.302–1.806 0.507
Pleural retraction sign 4.194 2.274–7.734  < 0.001 3.366 1.431–7.920 0.005
CT bronchus sign 3.529 2.064–6.035  < 0.001 2.608 1.190–5.714 0.017
Calcification 0.185 0.049–0.702 0.013 0.190 0.024–1.517 0.117
Mediastinal/hilar lymph nodule ≥ 10 mm 1.840 0.937–3.615 0.077 0.732 0.312–1.720 0.475
CEA 1.313 1.117–1.544 0.001 1.234 1.032–1.475 0.021
  1. CEA: Carcinoembryonic antigen; CI: confident interval; CT: computed tomography