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Table 2 Comparison of the CPET parameters of CTEPH subjects of different severity

From: Cardiopulmonary exercise testing and pulmonary function testing for predicting the severity of CTEPH

Variables

Rest

AT

Peak

Mild

Moderate

Severe

P

Mild

Moderate

Severe

P

Mild

Moderate

Severe

P

Load (W)

    

40.0 (35.5,48.5)

36.0 (28.0,41.0)

32.0 (24.0,42.0)

0.177

74.3 (66.4,106.0)

65.7 (56.0,84.7)

55.0 (42.7,72.0)

0.009

HR

84.1 ± 14.3

81.3 ± 11.5

82.4 ± 12.5

0.881

109.7 ± 22.7

110.0 ± 13.0

113.7 ± 16.1

0.727

135.0 ± 19.1

132.2 ± 20.2

128.6 ± 16.4

0.565

VO2 (mL/kg/min)

4.0 ± 0.5

5.1 ± 0.9

4.4 ± 0.8

0.017

9.3 ± 2.8

9.9 ± 1.2

9.1 ± 1.6

0.518

13.6 ± 3.5

12.8 ± 1.6

10.8 ± 2.2

0.013

VO2 (% pred)

17.1 ± 2.5

20.8 ± 4.4

18.8 ± 5.3

0.229

39.1 ± 8.3

41.1 ± 9.6

38.9 ± 12.5

0.872

57.4 ± 10.8

53.1 ± 12.1

46.4 ± 15.5

0.077

VO2/HR (mL)

3.2 ± 0.8

3.5 ± 0.8

3.5 ± 0.8

0.525

5.5 ± 1.6

5.0 ± 0.9

5.2 ± 1.3

0.647

6.7 ± 2.1

5.5 ± 1.1

5.5 ± 1.4

0.083

VE (L/min)

12.3 ± 2.5

13.1 ± 2.8

14.3 ± 3.2

0.158

26.0 ± 8.0

26.2 ± 4.5

32.2 ± 6.5

0.004

46.5 ± 12.4

43.2 ± 12.0

45.2 ± 12.6

0.835

BF (/min)

20.8 (16.9,24.7)

18.1 (15.3,23.3)

20.1 (17.3,23.0)

0.350

26.0 (18.8,34.5)

20.0 (17.8,31.3)

27.0 (23.0,31.0)

0.178

32.0 (25.5,45.1)

29.3 (23.9,37.9)

31.7 (29.3,35.7)

0.580

BR (%)

85.8 (84.0,88.3)

85.1 (83.0,87.8)

80.0 (77.8,85.3)

0.029

68.7 (65.9,76.7)

70.0 (58.1,77.0)

54.1 (42.2,67.3)

0.011

47.9 (40.4,56.7)

50.6 (28.8,58.0)

35.2 (25.4,54.1)

0.348

RER

0.88 ± 0.07

0.86 ± 0.06

0.85 ± 0.07

0.449

0.95 ± 0.07

0.95 ± 0.08

0.96 ± 0.06

0.815

1.15 ± 0.10

1.10 ± 0.10

1.10 ± 0.08

0.061

VE/VCO2

55.3 ± 9.9

54.7 ± 5.0

60.53 ± 9.1

0.085

46.6 ± 10.9

51.3 ± 8.2

58.9 ± 12.3

0.013

47.0 ± 11.1

55.7 ± 13.4

62.5 ± 15.2

0.010

VE/VO2

47.8 ± 5.9

47.3 ± 5.3

51.0 ± 6.6

0.157

44.3 ± 10.2

48.9 ± 10.7

57.5 ± 15.4

0.010

53.5 ± 12.2

61.9 ± 19.0

67.6 ± 19.7

0.106

PETCO2 (mm Hg)

27.7 ± 4.7

25.8 ± 2.1

23.9 ± 3.2

0.037

29.3 ± 5.4

25.2 ± 3.8

22.8 ± 4.4

0.004

28.5 ± 5.8

23.2 ± 5.1

21.3 ± 5.2

0.007

PETO2 (mm Hg)

119.8 ± 3.2

122.3 ± 3.4

122.9 ± 3.9

0.074

119.9 ± 5.6

125.1 ± 4.7

126.9 ± 4.9

0.006

124.7 ± 4.3

130.2 ± 5.6

130.2 ± 5.7

0.020

  1. Range for “Mild”: 35 > PAP (mm Hg) ≥ 25; range for “Moderate”: 45 > PAP (mm Hg) ≥ 35; range for “Severe”: PAP (mm Hg) ≥ 45. The data are presented as mean ± SD or median (interquartile range). Statistical analysis of characteristics of “Mild”, “Moderate” and “Severe” was analyzed with One-way ANOVA test or Kruskal–Wallis test, and was presented as “P”. VO2 = oxygen uptake; HR = heart rate; VE = minute ventilation; BF = breathing frequency; BR = breathing reserve; RER = respiratory exchange ratio; VCO2 = carbon dioxide output; PETCO2 = end-tidal partial pressure for carbon dioxide; PETO2 = end-tidal partial pressure for oxygen