From: Cardiopulmonary exercise testing and pulmonary function testing for predicting the severity of CTEPH
Variables | Rest | AT | Peak | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Mild | Moderate | Severe | P | Mild | Moderate | Severe | P | Mild | Moderate | Severe | P | |
Load (W) | 40.0 (35.5,48.5) | 36.0 (28.0,41.0) | 32.0 (24.0,42.0) | 0.177 | 74.3 (66.4,106.0) | 65.7 (56.0,84.7) | 55.0 (42.7,72.0) | 0.009 | ||||
HR | 84.1 ± 14.3 | 81.3 ± 11.5 | 82.4 ± 12.5 | 0.881 | 109.7 ± 22.7 | 110.0 ± 13.0 | 113.7 ± 16.1 | 0.727 | 135.0 ± 19.1 | 132.2 ± 20.2 | 128.6 ± 16.4 | 0.565 |
VO2 (mL/kg/min) | 4.0 ± 0.5 | 5.1 ± 0.9 | 4.4 ± 0.8 | 0.017 | 9.3 ± 2.8 | 9.9 ± 1.2 | 9.1 ± 1.6 | 0.518 | 13.6 ± 3.5 | 12.8 ± 1.6 | 10.8 ± 2.2 | 0.013 |
VO2 (% pred) | 17.1 ± 2.5 | 20.8 ± 4.4 | 18.8 ± 5.3 | 0.229 | 39.1 ± 8.3 | 41.1 ± 9.6 | 38.9 ± 12.5 | 0.872 | 57.4 ± 10.8 | 53.1 ± 12.1 | 46.4 ± 15.5 | 0.077 |
VO2/HR (mL) | 3.2 ± 0.8 | 3.5 ± 0.8 | 3.5 ± 0.8 | 0.525 | 5.5 ± 1.6 | 5.0 ± 0.9 | 5.2 ± 1.3 | 0.647 | 6.7 ± 2.1 | 5.5 ± 1.1 | 5.5 ± 1.4 | 0.083 |
VE (L/min) | 12.3 ± 2.5 | 13.1 ± 2.8 | 14.3 ± 3.2 | 0.158 | 26.0 ± 8.0 | 26.2 ± 4.5 | 32.2 ± 6.5 | 0.004 | 46.5 ± 12.4 | 43.2 ± 12.0 | 45.2 ± 12.6 | 0.835 |
BF (/min) | 20.8 (16.9,24.7) | 18.1 (15.3,23.3) | 20.1 (17.3,23.0) | 0.350 | 26.0 (18.8,34.5) | 20.0 (17.8,31.3) | 27.0 (23.0,31.0) | 0.178 | 32.0 (25.5,45.1) | 29.3 (23.9,37.9) | 31.7 (29.3,35.7) | 0.580 |
BR (%) | 85.8 (84.0,88.3) | 85.1 (83.0,87.8) | 80.0 (77.8,85.3) | 0.029 | 68.7 (65.9,76.7) | 70.0 (58.1,77.0) | 54.1 (42.2,67.3) | 0.011 | 47.9 (40.4,56.7) | 50.6 (28.8,58.0) | 35.2 (25.4,54.1) | 0.348 |
RER | 0.88 ± 0.07 | 0.86 ± 0.06 | 0.85 ± 0.07 | 0.449 | 0.95 ± 0.07 | 0.95 ± 0.08 | 0.96 ± 0.06 | 0.815 | 1.15 ± 0.10 | 1.10 ± 0.10 | 1.10 ± 0.08 | 0.061 |
VE/VCO2 | 55.3 ± 9.9 | 54.7 ± 5.0 | 60.53 ± 9.1 | 0.085 | 46.6 ± 10.9 | 51.3 ± 8.2 | 58.9 ± 12.3 | 0.013 | 47.0 ± 11.1 | 55.7 ± 13.4 | 62.5 ± 15.2 | 0.010 |
VE/VO2 | 47.8 ± 5.9 | 47.3 ± 5.3 | 51.0 ± 6.6 | 0.157 | 44.3 ± 10.2 | 48.9 ± 10.7 | 57.5 ± 15.4 | 0.010 | 53.5 ± 12.2 | 61.9 ± 19.0 | 67.6 ± 19.7 | 0.106 |
PETCO2 (mm Hg) | 27.7 ± 4.7 | 25.8 ± 2.1 | 23.9 ± 3.2 | 0.037 | 29.3 ± 5.4 | 25.2 ± 3.8 | 22.8 ± 4.4 | 0.004 | 28.5 ± 5.8 | 23.2 ± 5.1 | 21.3 ± 5.2 | 0.007 |
PETO2 (mm Hg) | 119.8 ± 3.2 | 122.3 ± 3.4 | 122.9 ± 3.9 | 0.074 | 119.9 ± 5.6 | 125.1 ± 4.7 | 126.9 ± 4.9 | 0.006 | 124.7 ± 4.3 | 130.2 ± 5.6 | 130.2 ± 5.7 | 0.020 |