Fig. 1

Longitudinal biomarker levels are elevated in progressive IPF patients. Serum levels of PRO-C6 (A) and C6M (B) are shown at baseline, six months and 12 months for stable (dark blue) and progressive (grey) patients with IPF. Disease progression was defined as ≥ 5% decline in FVC and/or ≥ 10% decline in DLCO or all-cause mortality within 12 months. Data are presented as geometric mean with 95% CI (error bars) adjusted for age and sex. The number of evaluable samples available for analysis at each time point is provided below the graphs. The interaction between timepoint and progression status was not significant for PRO-C6 (P = 0.66) and for C6M (P = 0.67). A significant average contrast across all timepoints between stable and progressors for PRO-C6 is shown as ** (P < 0.01)