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Table 3 Laboratory and clinical findings in patients with cryptogenic and secondary organizing pneumonia

From: Comparison of clinical features and prognosis in patients with cryptogenic and secondary organizing pneumonia

 

COP (n = 16)

SOP (n = 69)

Total OP (n = 85)

P

PF ratio

297 (270–330)

(n = 6)

281 (250–375)

(n = 45)

281 (254–367)

(n = 51)

0.853

SBP, mmHg

110 (100–120)

120 (110–130)

120 (110–130)

0.100

DBP, mmHg

70 (60–80)

70 (60–80)

70 (60–80)

0.861

PR, /min

85 (76–99)

90 (80–98)

89 (79–99)

0.582

RR, /min

20 (20–20)

20 (20–20)

20 (20–20)

0.401

BT, ℃

37.0 (36.8–37.5)

37.0 (36.7–37.4)

37.0 (36.7–37.4)

0.744

Day at admission

    

 Leukocyte, 103/ul

6.1 (5.1–9.4)

8.7 (6.6–13.7)

8.7 (6.2–13.6)

0.197

 Neutrophil, %

71 (66–79)

80 (72–86)

80 (71–85)

0.088

 Eosinophil, %

3 (2–3)

1 (0–2)

1 (0–2)

0.012*

 CRP, mg/l

11 (3–49)

108 (24–210)

83 (21–208)

0.067

 Procalcitonin, ng/ml

0.05 (0.03–0.05)

0.26 (0.11–1.45)

0.23 (0.08–1.53)

0.018*

 proBNP, pg/ml

223 (112–325)

985 (307–2387)

881 (251–2287)

0.035*

 D-dimer, ug/ml

0.9 (0.3–1.3)

2.0 (1.3–2.8)

1.9(1.0–2.7)

0.015*

 Albumin, g/dl

3.6 (3.3–3.8)

3.3 (3.1–3.7)

3.3 (3.1–3.7)

0.260

 Creatinine, mg/dl

0.7 (0.6–0.8)

1.0 (0.7–1.3)

1.0 (0.7–1.3)

0.012*

 Lactate, mmol/l

1.0 (1.0–1.1)

1.4 (1.1–1.9)

1.4 (1.0–1.9)

0.047*

Bronchoalveolar lavage

COP (n = 9)

SOP (n = 35)

OP (n = 44)

P

Leukocyte, /ul

380 (200–600)

270 (150–850)

300 (150–700)

0.895

Neutrophil, %

7 (4–13)

15 (5–67)

10 (4–56)

0.132

Lymphocyte, %

60 (38–83)

31 (7–56)

36 (9–61)

0.012*

Eosinophil, %

0 (0–1)

1 (1–3)

1 (0–2)

0.007*

Pulmonary function tests**

COP (n = 10)

SOP (n = 31)

OP (n = 41)

0.303

 Normal

6 (60.0)

10 (32.3)

16 (39.0)

 

 Restrictive ventilatory defect

3 (30.0)

9 (29.0)

12 (29.3)

 

 Obstructive ventilatory defect

1 (10.0)

8 (25.8)

9 (22.0)

 

 Mixed ventilatory defect

0

4 (12.9)

4 (9.8)

 
  1. Data are presented as number (%) or median (interquartile range [IQR])
  2. COP cryptogenic organizing pneumonia, SOP secondary organizing pneumonia, OP organizing pneumonia, PF ratio arterial partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio, CRP C-reactive protein, proBNP pro-brain natriuretic peptide, ESR erythrocyte sedimentation rate, FVC forced vital capacity, FEV1 forced expiratory volume in the first second, TLC total lung capacity, DLCO diffusing capacity of the lung for carbon monoxide
  3. *P < 0.05 by Mann–Whitney U-tests for comparisons between the COP and SOP groups
  4. **Classified as normal, restrictive, obstructive, and mixed pattern according to American Thoracic Society criteria [23]