Fig. 9

%Muscularization and %MWT in rats injected with monocrotaline (MCT) and exposed to chronic hypoxia (CH). The data were obtained from the MCT21 model (rats fed with and without CLZ for 21 days after the injection of saline or MCT) and CH model (rats fed with and without CLZ for 14 days during exposure to ambient air or chronic hypoxia). %Muscularization, the percentages of muscularized arteries in peripheral pulmonary arteries with an external diameter between 15 and 50 µm (A and D) and those with an external diameter between 51 and 100 µm (B and E). %MWT, %Medial wall thickness, is the ratio of the wall thickness of the media (distance between external and internal elastic laminae) to the external diameter in muscular arteries with diameters ranging from 101 to 200 µm (C and F). Sal21/CLZ-, rats injected with saline and fed rat chow without cilostazol (CLZ); Sal21/CLZ +, rats injected with saline and fed rat chow with CLZ; MCT21/CLZ-, rats injected with MCT and fed rat chow without CLZ; MCT21/CLZ +, rats injected with MCT and fed rat chow with CLZ; Air/CLZ-, rats exposed to ambient air and fed rat chow without CLZ; Air/CLZ +, rats exposed to ambient air and fed rat chow with CLZ; CH/CLZ-, rats exposed to chronic hypoxia and fed rat chow without CLZ; CH/CLZ +, rats exposed to chronic hypoxia and fed rat chow with CLZ. (n) = numbers of rats, means ± SE