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Table 4 Analysis of Predictors of Mortality in the Patients

From: Prognostic value of radiological findings indeterminate for UIP pattern and anterior upper lobe honeycomb-like lesion in chronic fibrosing interstitial lung disease associated with MPO-ANCA

 

Univariate Cox regression

Multivariate Cox regression

 

HR

95% CI

P-value

HR

95% CI

P-value

Age

1.054

1.003, 1.107

0.039

1.070

1.008, 1.135

0.026

Male

1.534

0.688, 3.420

0.296

 − 

  

Current/ex-smoker

2.094

0.871, 5.033

0.099

 − 

  

BMI

0.999

0.872, 1.144

0.985

 − 

  

HRCT pattern

   

 − 

  

UIP

1.000

Reference

   

Probable UIP

0.559

0.201, 1.554

0.265

   

Indeterminate for UIP

0.295

0.080, 1.083

0.066

   

CT sign

      

Emphysema

1.513

0.559, 4.092

0.415

 − 

  

Anterior upper lobe honeycomb-like lesion

2.751

1.151, 6.575

0.023

3.354

1.304, 8.629

0.012

Increased attenuation around honeycomb or traction bronchiectasis

1.038

0.468, 2.301

0.927

 − 

  

Honeycomb

2.175

0.881, 5.37

0.092

 − 

  

Concomitant with MPA (MPA-ILD)

1.056

0.463, 2.408

0.897

 − 

  

Acute exacerbation of ILD

1.329

0.524, 3.368

0.549

 − 

  

Diffuse pulmonary hemorrhage

11.363

3.619, 35.67

 < 0.001

9.822

2.977, 32.406

 < 0.001

CRP

1.196

1.051, 1.363

0.007

1.250

1.081, 1.444

0.003

%FVC

0.986

0.956, 1.017

0.381

 − 

  

%DLCO

0.990

0.962, 1.020

0.526

 − 

  

Anti-inflammatory agent

0.952

0.425, 2.129

0.904

 − 

  

Anti-fibrotic agent

0.629

0.146, 2.704

0.533

 − 

  
  1. BMI = body mass index; CI = confidence interval; CRP = C-reactive protein; CT = computed tomography; DLCO = diffusing capacity of the lung for carbon monoxide; FVC = forced vital capacity; HR = hazard ratio; HRCT = high-resolution CT; ILD = interstitial lung disease; MPA = microscopic polyangiitis; UIP = usual interstitial pneumonia