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Table 3 Large neutral amino acid plasma concentrations, whole body production rates, and clearance rates in COPD non-depressed and COPD depressed

From: Disturbances in branched-chain amino acid profile and poor daily functioning in mildly depressed chronic obstructive pulmonary disease patients

 

COPD non-depressed (CN)

(n = 51)

COPD depressed (CD)

(n = 27)

Estimated difference

ANCOVA

p value

Plasma concentrations (μmol/L)

 Tryptophan

35.76 [33.64, 37.89]

35.24 [31.77, 38.71]

− 0.26 [− 2.79, 2.27]

0.783

 Tryptophan corrected for large neutral amino acids

  

1.07 [− 3.39, 5.53]

0.656

 Tyrosine

54.23 [50.65, 57.80]

47.11 [43.14, 51.08]

− 8.13 [− 13.63, − 2.63]

0.005

 Tyrosine corrected for large neutral amino acids

  

− 5.58 [− 10.99, − 0.17]

0.048

 Phenylalanine

48.54 [45.71, 51.38]

43.40 [40.55, 47.57]

− 5.75 [− 9.86, − 1.64]

0.008

 Leucine

110.50 [98.87, 122.10]

95.95 [79.09, 106.70]

− 18.77 [− 34.54, − 2.99]

0.031

 Isoleucine

65.79 [58.34, 73.23]

53.83 [41.92, 63.58]

− 15.11 [− 24.20, − 6.02]

0.003

 Valine

177.60 [162.70, 192.40]

163.30 [137.20, 177.70]

− 20.67 [− 42.12, 0.80]

0.090

 Sum branched chain amino acids

332.40 [306.40, 358.40]

294.70 [243.10, 327.90]

− 49.57 [− 86.83, − 12.32]

0.016

 Sum large neutral amino acids

435.20 [406.50, 463.90]

385.20 [322.20, 430.30]

− 63.42 [− 104.03, − 22.79]

0.005

Whole body production rates (μmol/h)

 Phenylalanine

3507.33 [3250.40, 3764.27]

4022.20 [3522.65, 4521.75]

271.60 [− 286.95, 830.06]

0.214

 Tyrosine

3188.99 [2894.67, 3483.31]

3618.15 [3059.27, 4177.04]

107.01 [− 514.88, 728.98]

0.581

 Tryptophan

1175.83 [1026.55, 1325.11]

1326.93 [1088.30, 1565.57]

114.50 [− 145.50, 374.50]

0.382

 Isoleucine

3673.94 [3094.86, 4253.01]

3989.06 [3155.51, 4822.61]

362.20 [− 623.90, 1348.00]

0.465

 Valine

11,119.21 [9712.82, 12,525.61]

11,880.31 [9962.54, 11,602.38]

276.61 [− 1423.95, 1976.60]

0.570

 Leucine

9782.64 [8789.57, 10,775.71]

10,352.46 [9102.55, 12,188.00]

− 3.91 [− 1384.21, 1376.47]

0.811

 Phenylalanine to tyrosine (net protein breakdown)

216.80 [179.40, 235.00]

267.50 [200.50, 287.20]

34.51 [− 7.93, 76.96]

0.104

 Branched chain amino acids

24,783.00 [21684.00, 27,881.00]

26,808.00 [20235.00, 31,134.00]

1354.79 [− 2141.15, 4851.15]

0.315

Clearance rates (L h−1)

 Leucine

1.98 [1.79, 2.18]

2.24 [1.78, 2.64]

0.34 [0.08, 0.60]

0.013

 Valine

1.35 [1.24, 1.47]

1.47 [1.18, 1.76]

0.18 [0.004, 0.36]

0.071

 Isoleucine

1.30 [1.09, 1.50]

1.51 [1.00, 1.74]

0.33 [− 0.08, 0.74]

0.133

 Phenylalanine

1.55 [1.46, 1.64]

1.88 [1.51, 2.18]

0.30 [0.11, 0.49]

0.003

 Tryptophan

0.72 [0.65, 0.80]

0.77 [0.62, 0.95]

0.06 [− 0.08, 0.21]

0.371

  1. Values are mean [95% CI], except for when data was log-transformed for which geometric mean [95% CI] was used. LNAA: Large neutral amino acids. BCAA: Branched chain amino acids. WBP: Whole body production. Statistics are by ANCOVA with age and BMI as covariates, normal text is untransformed data and italicized is log-transformed data, bold is P < 0.05