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Table 2 Performance of HT-NGS and conventional microbiological testing in the diagnosis of pulmonary infection in lung transplant recipients

From: High-throughput next-generation sequencing for identifying pathogens during early-stage post-lung transplantation

   Infection (35) Non-infection (16) Sensitivity% (95%CI) Specificity% (95%CI) PPV% (95%CI) NPV% (95%CI)
HT-NGS + 34 11 97.14 (83.38–99.85) 31.25 (12.13–58.52) 75.56 (60.14–86.61) 83.33 (36.48–99.12)
  1 5     
Conventional microbiological testing + 24 6 68.57 (50.58–82.57) 62.50 (35.87–83.72) 80.00 (60.87–91.60) 47.62 (26.39–69.66)
  11 10     
  1. HT-NGS high-throughput next-generation sequencing, PPV positive predictive value, NPV negative predictive value