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Table 2 Comparisons of CPET data with SOT and HFNC oxygen therapy

From: Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial

 

SOT (n = 10)

HFNC (n = 10)

p value

Tlim (s)

381 (137)

494 (173)

0.013

O2 flow (l)

 Initial

8 (2.8)

40 (0)

< 0.01

 End of test

9.1 (4.1)

45 (8.5)

< 0.01

VT (ml)

 Initial

710 (174)

646 (158)

0.20

 End of test

1310 (466)

1333 (518)

1

 Change (%)a

89 (27)

100 (54)

1

RR (rpm)

 Initial

27 (10)

26 (8)

0.16

 End of test

44 (11)

43 (10)

0.87

VE (%pred.)

   

 Initial

27 (7)

25 (8)

0.17

 End of test

81 (15)

78 (13)

0.46

IC (l)

 Initial

1.4 (0.5)

1.4 (0.5)

0.83

 End of test

1.5 (0.6)

1.7 (0.6)

0.53

 Change (%)a

7.1 (8.9)

19.4 (14.2)

0.04

HR (bpm)

 Initial

84 (16)

84 (16)

0.76

 End of test

122 (17)

123 (20)

0.72

 Isotime

118 (15)

118 (20)

0.92

HR (%pred.)

 Initial

56 (10)

56 (11)

0.80

 End of test

82 (10)

82 (12)

0.77

SpO2 (%)

 Initial

97 (2)

97 (1)

0.72

 End of test

90 (4)

90 (3)

1

StO2 (%)b

 Initial

45 (7.2)

47.1 (9.3)

0.35

 End of test

43.4 (9.6)

47.2 (10.6)

0.12

Borg scale

 Initial

  Dyspnea

0.1 (0.3)

0.2 (0.4)

0.32

  Leg fatigue

0 (0)

0.2 (0.6)

0.32

 End of test

  Dyspnea

6.6 (1.8)

6.7 (2.4)

0.91

  Leg fatigue

5.1 (3.4)

4.9 (3.1)

0.83

  1. Each parameter is expressed as mean (standard deviation)
  2. CPET constant work pulmonary exercise test, SOT standard oxygen therapy, HFNC high-flow nasal cannula, Tlim endurance time, s seconds, O2 oxygen, VT tidal volume, RR respiratory rate, rpm respirations per minute, VE pulmonary ventilation, IC inspiratory capacity, HR heart rate, bpm beats per minute, SpO2 peripheral oxygen saturation, StO2 peripheral muscle oxygen saturation
  3. aChange (end of test value − initial value/initial value) * 100
  4. bMeasured in n = 7 subjects