Association of genetic variants of oxidative stress responsive kinase 1 (OXSR1) with asthma exacerbations in non-smoking asthmatics

Table 2 Association of SNPs and haplotypes of OXSR1 with the number of exacerbations during the 1st year of follow up in non-smoker subjects

Locus	No. of exacerbations, Mean ± SE (N)			Codomiant		Dominant		Recessive
Locus	CC	CR	RR	P*	Pcorr	P*	Pcorr	P*	Pcorr
rs9839010	0.41 ± 0.03 (600)	0.28 ± 0.03 (308)	0.34 ± 0.11 (47)	0.038	0.383	0.011	0.114	0.268	1.000
rs61005484	0.38 ± 0.03 (845)	0.25 ± 0.06 (108)	0.5 ± 0.5 (2)	0.445	1.000	0.218	1.000	0.881	1.000
rs4955408	0.31 ± 0.04 (342)	0.44 ± 0.04 (462)	0.28 ± 0.05 (150)	0.081	0.811	0.090	0.905	0.411	1.000
rs1392283	0.39 ± 0.03 (758)	0.27 ± 0.04 (183)	0.15 ± 0.1 (13)	0.045	0.453	0.013	0.128	0.597	1.000
rs112221585	0.37 ± 0.03 (817)	0.33 ± 0.07 (131)	0.33 ± 0.33 (3)	0.846	1.000	0.566	1.000	0.875	1.000
rs74919163	0.31 ± 0.03 (481)	0.46 ± 0.04 (389)	0.21 ± 0.07 (66)	0.041	0.413	0.031	0.307	0.532	1.000
rs1384006	0.43 ± 0.04 (541)	0.28 ± 0.03 (356)	0.31 ± 0.09 (58)	0.015	0.153	0.004	0.039	0.476	1.000
rs156260	0.37 ± 0.03 (736)	0.36 ± 0.06 (206)	0 ± 0 (13)	0.635	1.000	0.928	1.000	0.344	1.000
rs9880223	0.38 ± 0.03 (845)	0.25 ± 0.06 (108)	0.5 ± 0.5 (2)	0.445	1.000	0.218	1.000	0.881	1.000
rs2298417	0.35 ± 0.03 (683)	0.4 ± 0.05 (247)	0.58 ± 0.15 (24)	0.120	1.000	0.131	1.000	0.080	0.802
rs2011	0.4 ± 0.03 (634)	0.3 ± 0.04 (284)	0.24 ± 0.09 (37)	0.067	0.673	0.020	0.201	0.490	1.000
Block1_ht1	0.34 ± 0.05 (216)	0.42 ± 0.04 (506)	0.28 ± 0.04 (233)	0.120	0.360	0.077	0.231	0.646	1.000
Block1_ht2	0.3 ± 0.06 (108)	0.44 ± 0.04 (435)	0.3 ± 0.03 (412)	0.029	0.087	0.025	0.075	0.513	1.000
Block2_ht2	0.47 ± 0.14 (34)	0.37 ± 0.05 (309)	0.36 ± 0.03 (612)	0.768	1.000	0.814	1.000	0.469	1.000

The italic, underlined P values indicate statistical significance (P < 0.05)
CC common allele homozygote, CR heterozygote, RR minor allele homozygote, SE standard error of mean, Pcorr corrected P value for multiple comparisons
Pcorr corrected P values using the effective number of independent marker loci (M_effLi) calculated by SNPSpD for each SNP (M_effLi = 10.03501), and using the number of haplotypes (n = 3) for each haplotypes
*Adjusted for age, sex, serum total IgE level, predicted FEV1% at the first visit, and total ICS and systemic steroid dose in the 1st year of visit as covariates

ISSN: 1471-2466