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Table 3 Association between BMI and primary anti-tuberculosis resistance

From: Association between body mass index and newly diagnosed drug-resistant pulmonary tuberculosis in Shandong, China from 2004 to 2019

The type of drug resistance

Univariable analysis

Multivariable analysis

OR (95%CI)

P value

aOR (95%CI)

P value

Underweight group vs Normal weight group

    

DR-TB

0.96 (0.846–1.09)

0.532

0.977 (0.86–1.111)

0.726

MR-TB

1.041 (0.893–1.215)

0.606

1.056 (0.904–1.233)

0.493

MDR-TB

0.891 (0.672–1.182)

0.424

0.928 (0.698–1.235)

0.610

PDR-TB

0.801 (0.614–1.044)

0.101

0.804 (0.615–1.052)

0.112

INH-related resistance

0.994 (0.846–1.169)

0.944

0.948 (0.746–1.203)

0.659

RFP-related resistance

0.91 (0.719–1.153)

0.436

0.948 (0.746–1.203)

0.659

SM-related resistance

0.844 (0.726–0.982)

0.028*

0.869 (0.746–1.012)

0.071

MR-TB (INH)

1.347 (1.049–1.730)

0.020*

1.31 (1.017–1.686)

0.037*

INH + SM resistance

0.754 (0.558–1.019)

0.066

0.751 (0.554–1.018)

0.065

INH + RFP + SM resistance

0.834 (0.555–1.255)

0.384

0.881 (0.585–1.328)

0.546

Any INH + SM resistance

0.818 (0.656–1.019)

0.073

0.831 (0.665–1.039)

0.105

Susceptible

Reference

Reference

Reference

Reference

Overweight group vs Normal weight group

    

DR-TB

1.101 (0.849–1.428)

0.467

1.082 (0.832–1.407)

0.559

MR-TB

0.879 (0.617–1.253)

0.476

0.854 (0.596–1.225)

0.391

MDR-TB

1.603 (1.002–2.566)

0.049*

1.639 (1.02–2.633)

0.041*

PDR-TB

1.299 (0.812–2.076)

0.275

1.284 (0.8–2.06)

0.300

INH-related resistance

1.251 (0.912–1.717)

0.165

1.248 (0.907–1.716)

0.174

RFP-related resistance

1.29 (0.833–1.997)

0.253

1.271 (0.817–1.977)

0.287

SM-related resistance

1.234 (0.927–1.641)

0.149

1.224 (0.916–1.636)

0.171

MR-TB (INH)

0.734 (0.374–1.443)

0.371

0.736 (0.373–1.449)

0.375

INH + SM resistance

1.361 (0.82–2.26)

0.234

1.36 (0.815–2.268)

0.239

INH + RFP + SM resistance

1.948 (1.061–3.577)

0.032*

2.113 (1.141–3.912)

0.017*

Any INH + SM resistance

1.472 (1.013–2.14)

0.043*

1.483 (1.017–2.164)

0.041*

Susceptible

Reference

Reference

Reference

Reference

Obese group vs Normal weight group

    

DR-TB

0.739 (0.374–1.46)

0.384

0.741 (0.374–1.469)

0.391

MR-TB

1.658 (0.766–3.587)

0.199

1.62 (0.747–3.516)

0.222

MDR-TB

–

–

–

–

PDR-TB

1.653 (0.505–5.409)

0.406

1.712 (0.52–5.637)

0.377

INH-related resistance

0.945 (0.372–2.399)

0.905

0.943 (0.37–2.403)

0.901

RFP-related resistance

–

–

–

–

SM-related resistance

0.639 (0.307–1.328)

0.230

0.644 (0.308–1.347)

0.243

MR-TB (INH)

1.350 (0.325–5.607)

0.679

1.304 (0.313–5.435)

0.715

INH + SM resistance

2.038 (0.622–6.678)

0.240

2.089 (0.633–6.892)

0.226

INH + RFP + SM resistance

–

–

–

–

Any INH + SM resistance

1.136 (0.348–3.709)

0.833

1.148 (0.349–3.775)

0.820

Susceptible

Reference

Reference

Reference

Reference

  1. TB, tuberculosis; DR-TB, drug-resistant tuberculosis; MR-TB, mono-resistant tuberculosis; MDR-TB, multidrug resistant tuberculosis; PDR-TB, polydrug resistant tuberculosis; EMB, ethambutol; INH, isoniazid; RFP, rifampin; SM, streptomycin; BMI, body mass index; aOR, adjusted odds ratio; OR, odds ratio;*P < 0.05
  2. Underweight: BMI < 18.5 kg/m2; Normal weight: 18.5 kg/m2 ≥ BMI ≤ 24.9 kg/m2; Overweight: 25 kg/m2 ≥ BMI ≤ 29.9 kg/m2; Obese: BMI ≥ 30 kg/m2