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Table 3 Association between BMI and primary anti-tuberculosis resistance

From: Association between body mass index and newly diagnosed drug-resistant pulmonary tuberculosis in Shandong, China from 2004 to 2019

The type of drug resistance Univariable analysis Multivariable analysis
OR (95%CI) P value aOR (95%CI) P value
Underweight group vs Normal weight group     
DR-TB 0.96 (0.846–1.09) 0.532 0.977 (0.86–1.111) 0.726
MR-TB 1.041 (0.893–1.215) 0.606 1.056 (0.904–1.233) 0.493
MDR-TB 0.891 (0.672–1.182) 0.424 0.928 (0.698–1.235) 0.610
PDR-TB 0.801 (0.614–1.044) 0.101 0.804 (0.615–1.052) 0.112
INH-related resistance 0.994 (0.846–1.169) 0.944 0.948 (0.746–1.203) 0.659
RFP-related resistance 0.91 (0.719–1.153) 0.436 0.948 (0.746–1.203) 0.659
SM-related resistance 0.844 (0.726–0.982) 0.028* 0.869 (0.746–1.012) 0.071
MR-TB (INH) 1.347 (1.049–1.730) 0.020* 1.31 (1.017–1.686) 0.037*
INH + SM resistance 0.754 (0.558–1.019) 0.066 0.751 (0.554–1.018) 0.065
INH + RFP + SM resistance 0.834 (0.555–1.255) 0.384 0.881 (0.585–1.328) 0.546
Any INH + SM resistance 0.818 (0.656–1.019) 0.073 0.831 (0.665–1.039) 0.105
Susceptible Reference Reference Reference Reference
Overweight group vs Normal weight group     
DR-TB 1.101 (0.849–1.428) 0.467 1.082 (0.832–1.407) 0.559
MR-TB 0.879 (0.617–1.253) 0.476 0.854 (0.596–1.225) 0.391
MDR-TB 1.603 (1.002–2.566) 0.049* 1.639 (1.02–2.633) 0.041*
PDR-TB 1.299 (0.812–2.076) 0.275 1.284 (0.8–2.06) 0.300
INH-related resistance 1.251 (0.912–1.717) 0.165 1.248 (0.907–1.716) 0.174
RFP-related resistance 1.29 (0.833–1.997) 0.253 1.271 (0.817–1.977) 0.287
SM-related resistance 1.234 (0.927–1.641) 0.149 1.224 (0.916–1.636) 0.171
MR-TB (INH) 0.734 (0.374–1.443) 0.371 0.736 (0.373–1.449) 0.375
INH + SM resistance 1.361 (0.82–2.26) 0.234 1.36 (0.815–2.268) 0.239
INH + RFP + SM resistance 1.948 (1.061–3.577) 0.032* 2.113 (1.141–3.912) 0.017*
Any INH + SM resistance 1.472 (1.013–2.14) 0.043* 1.483 (1.017–2.164) 0.041*
Susceptible Reference Reference Reference Reference
Obese group vs Normal weight group     
DR-TB 0.739 (0.374–1.46) 0.384 0.741 (0.374–1.469) 0.391
MR-TB 1.658 (0.766–3.587) 0.199 1.62 (0.747–3.516) 0.222
MDR-TB
PDR-TB 1.653 (0.505–5.409) 0.406 1.712 (0.52–5.637) 0.377
INH-related resistance 0.945 (0.372–2.399) 0.905 0.943 (0.37–2.403) 0.901
RFP-related resistance
SM-related resistance 0.639 (0.307–1.328) 0.230 0.644 (0.308–1.347) 0.243
MR-TB (INH) 1.350 (0.325–5.607) 0.679 1.304 (0.313–5.435) 0.715
INH + SM resistance 2.038 (0.622–6.678) 0.240 2.089 (0.633–6.892) 0.226
INH + RFP + SM resistance
Any INH + SM resistance 1.136 (0.348–3.709) 0.833 1.148 (0.349–3.775) 0.820
Susceptible Reference Reference Reference Reference
  1. TB, tuberculosis; DR-TB, drug-resistant tuberculosis; MR-TB, mono-resistant tuberculosis; MDR-TB, multidrug resistant tuberculosis; PDR-TB, polydrug resistant tuberculosis; EMB, ethambutol; INH, isoniazid; RFP, rifampin; SM, streptomycin; BMI, body mass index; aOR, adjusted odds ratio; OR, odds ratio;*P < 0.05
  2. Underweight: BMI < 18.5 kg/m2; Normal weight: 18.5 kg/m2 ≥ BMI ≤ 24.9 kg/m2; Overweight: 25 kg/m2 ≥ BMI ≤ 29.9 kg/m2; Obese: BMI ≥ 30 kg/m2