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Table 2 Respiratory function indices in patients with CTEPH

From: Vascular involvement in chronic thromboembolic pulmonary hypertension is associated with spirometry obstructive impairment

  Measured values Expected values p value
VC (L) 2.55 (2.05–3.07) 2.57 (2.33–2.92) < 0.001**
%VC 94.8 (83.1–101.7)   
FVC (L) 2.55 (1.98–3.00) 2.48 (2.26–2.83) < 0.001**
%FVC 94.6 (84.2–105.1)   
FEV1.0 (L) 1.91 (1.47–2.32) 2.04 (1.82–2,46) < 0.001**
FEV1.0/FVC (%) 76.0 (70.0–82.1) 81.9 (79.3–85.9) < 0.001**
%FEV1.0 83.6 (73.8–98.3)   
MMF (L) 1.40 (0.87–2.17) 2.60 (2.30–3.10) < 0.001**
%MMF 48.9 (35.1–71.6)   
\({\dot{\text{V}}}\)50 2.02 (1.28–2.75) 2.95 (2.66–3.5) < 0.001**
%\({\dot{\text{V}}}\)50 59.9 (42.9–82.6)   
\({\dot{\text{V}}}\)25 (L) 0.47 (0.29–0.82) 1.06 (0.87–1.39) < 0.001**
%\({\dot{\text{V}}}\)25 41.8 (29.0–58.5)   
PEF (L/s) 5.54 (4.42–6.67) 5.62 (5.37–6.08) < 0.001**
> 5% of ATI, n (%) 24 (17.8%)   
Restrictive ventilatory impairment, n (%) 22 (16.3%)   
Obstructive ventilatory impairment, n (%) 34 (25.2%)   
Mixed ventilatory impairment, n (%) 3 (2.2%)   
DLco (mL/min/mmHg) 13.1 (10.9–16.0) 17.0 (15.1–20.1) < 0.001**
%DLco 77.0 (64.8–86.5)   
TLC (L) 4.77 (3.92–5.64) 4.44 (4.11–4.97) N.S
RV (L) 1.86 (1.58–2.24) 1.82 (1.69–1.96) N.S
RV/TLC (%) 39.9 (35.4–43.9)   
  1. Values are expressed as the median with the interquartile range
  2. VC, vital capacity; FEV1.0, forced expiratory volume in 1 second; FVC, forced vital capacity; MMF, maximal mid‒expiratory flow; \({\dot{\text{V}}}\)50 and \({\dot{\text{V}}}\)25, flow at 50,and 25% of vital capacity; PEF, peak expiratory flow; ATI, air trapping index; DLco, diffused capacity of carbon monoxide; TLC, total lung capacity; RV, residual volume
  3. **p < 0.01