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Table 1 Clinicopathological features of 10 patients with IgG4-related lung disease

From: Clinicopathological characteristics of IgG4-related lung disease

Case No

Age (years)

Sex

Clinical features

Serological findings

Diagnostic technique

Histopathological examination

Initial symptoms

OOI

IgG4 (g/l)

ESR (mm/h)

hs-CRP (mg/l)

NSE (ng/ml)

CYFRA 21-1 (ng/ml)

CEA (ng/ml)

CA125 (U/ml)

IgG4 + (/HPF)

IgG + (/HPF)

IgG4 + /IgG + (%)

1

65

F

No

No

NA

8

1.2

17.2

3.1

1.9

10.6

VATS

97

214

45.3

2

50

M

No

Lymph node

NA

20

0.3

10.4

3.5

1.9

6.9

VATS

78

175

44.6

3

58

M

Cough, hemoptysis

No

NA

18

1.0

10.7

4.1

1.5

1.5

VATS

52

130

40.0

4

64

M

Chest pain

Nasal sinus

NA

61

9.5

8.4

3.8

2.4

29.3

VATS

56

129

43.4

5

58

M

Cough, low-grade fever

Lymph node

4.6

101

156.8

9.3

1.8

1.4

13.3

OLB

65

151

43.0

6

58

M

Back pain

Lymph node, nasal sinus

11.7

95

117.3

7.7

2.5

2.5

10.1

PLB

29

112

25.9

7

64

M

No

Lymph node, nasal sinus

3.3

77

49.7

11.0

1.7

1.2

9.5

TLB

43

195

22.1

8

56

M

Cough, hemoptysis

Lymph node

8.6

52

23.3

10.7

2.7

1.1

10.0

TLB

122

248

49.2

9

67

M

Cough

Lymph node

7.3

87

25.8

10.6

2.3

0.9

18.7

TLB

34

113

30.1

10

57

M

Ocular symptoms

Lymph node, pituitary, lacrimal, parotid and submandibular gland

56.3

92

3.0

8.2

2.1

0.7

17.3

TLB

40

62

64.5

  1. Normal ranges are as follows: IgG4 0.03–2.01 g/l, ESR 0–15 mm/h, hs-CRP 0–3 mg/l, NSE ≤ 16.3 ng/ml, CYFRA 21-1 ≤ 3.3 ng/ml, CEA ≤ 5 ng/ml, CA125 ≤ 35 U/ml. OOI other organ involvement, IgG4 immunoglobulin G4, ESR erythrocyte sedimentation rate, hs-CRP high-sensitivity C-reactive protein, NSE neuron-specific enolase, CYFRA 21-1 cytokeratin fraction 21-1, CEA carcinoembryonic antigen, CA125 cancer antigen 125, HPF high-power field, IgG immunoglobulin G, F female, M male, NA data not available, VATS video-assisted thoracoscopic surgery, OLB open lung biopsy, PLB percutaneous lung biopsy, TLB transbronchial lung biopsy