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Table 1 Clinicopathological features of 10 patients with IgG4-related lung disease

From: Clinicopathological characteristics of IgG4-related lung disease

Case No Age (years) Sex Clinical features Serological findings Diagnostic technique Histopathological examination
Initial symptoms OOI IgG4 (g/l) ESR (mm/h) hs-CRP (mg/l) NSE (ng/ml) CYFRA 21-1 (ng/ml) CEA (ng/ml) CA125 (U/ml) IgG4 + (/HPF) IgG + (/HPF) IgG4 + /IgG + (%)
1 65 F No No NA 8 1.2 17.2 3.1 1.9 10.6 VATS 97 214 45.3
2 50 M No Lymph node NA 20 0.3 10.4 3.5 1.9 6.9 VATS 78 175 44.6
3 58 M Cough, hemoptysis No NA 18 1.0 10.7 4.1 1.5 1.5 VATS 52 130 40.0
4 64 M Chest pain Nasal sinus NA 61 9.5 8.4 3.8 2.4 29.3 VATS 56 129 43.4
5 58 M Cough, low-grade fever Lymph node 4.6 101 156.8 9.3 1.8 1.4 13.3 OLB 65 151 43.0
6 58 M Back pain Lymph node, nasal sinus 11.7 95 117.3 7.7 2.5 2.5 10.1 PLB 29 112 25.9
7 64 M No Lymph node, nasal sinus 3.3 77 49.7 11.0 1.7 1.2 9.5 TLB 43 195 22.1
8 56 M Cough, hemoptysis Lymph node 8.6 52 23.3 10.7 2.7 1.1 10.0 TLB 122 248 49.2
9 67 M Cough Lymph node 7.3 87 25.8 10.6 2.3 0.9 18.7 TLB 34 113 30.1
10 57 M Ocular symptoms Lymph node, pituitary, lacrimal, parotid and submandibular gland 56.3 92 3.0 8.2 2.1 0.7 17.3 TLB 40 62 64.5
  1. Normal ranges are as follows: IgG4 0.03–2.01 g/l, ESR 0–15 mm/h, hs-CRP 0–3 mg/l, NSE ≤ 16.3 ng/ml, CYFRA 21-1 ≤ 3.3 ng/ml, CEA ≤ 5 ng/ml, CA125 ≤ 35 U/ml. OOI other organ involvement, IgG4 immunoglobulin G4, ESR erythrocyte sedimentation rate, hs-CRP high-sensitivity C-reactive protein, NSE neuron-specific enolase, CYFRA 21-1 cytokeratin fraction 21-1, CEA carcinoembryonic antigen, CA125 cancer antigen 125, HPF high-power field, IgG immunoglobulin G, F female, M male, NA data not available, VATS video-assisted thoracoscopic surgery, OLB open lung biopsy, PLB percutaneous lung biopsy, TLB transbronchial lung biopsy