Transcatheter radiofrequency pulmonary artery denervation in swine: the evaluation of lesion degree, hemodynamics and pulmonary hypertension inducibility

Table 1 Baseline hemodynamic characteristics of the three groups (Kruskal–Wallis ANOVA, mean ± SD)

Parameters	All pigs, n = 17	Group I (PH-PADN), n = 9	Group II (non PH-PADN), n = 4	Group III (PH-shamPADN) n = 4	p value
HR, beat/min	97.5 ± 15.4	96.9 ± 11.0	97.8 ± 29.2	98.8 ± 9.1	0.86
SBP, mmHg	94.0 ± 11.5	93.1 ± 10.3	90.3 ± 12.6	99.8 ± 13.7	0.47
DBP, mmHg	54.0 ± 7.7	55.9 ± 5.8	50.5 ± 3.1	53.3 ± 13.7	0.21
mBP, mm Hg	66.8 ± 9.2	67.1 ± 8.5	64.3 ± 6.4	68.8 ± 14.3	0.80
SPAP, mm Hg	16.8 ± 3.9	17.2 ± 4.5	15.3 ± 3.3	17.3 ± 2.6	0.52
DPAP, mm Hg	12.0 ± 3.5	12.4 ± 3.8	10.3 ± 1.7	12.8 ± 4.3	0.58
mPAP, mm Hg	13.5 ± 3.7	13.9 ± 4.0	11.8 ± 2.5	14.5 ± 4.0	0.54
RAP, mm Hg	3.5 ± 2.2	3.9 ± 2.0	2.3 ± 1.5	4.0 ± 3.2	0.36
PCWP, mm Hg	4.4 ± 1.8	4.4 ± 2.1	3.8 ± 1.3	4.8 ± 1.7	0.74
CO, l/min	4.5 ± 1.5	4.7 ± 1.8	5.1 ± 1.3	3.4 ± 0.7	0.21
PVR, dyn/s/sm⁻⁵	186.6 ± 94.4	181.7 ± 85.4	139.7 ± 73.8	244.8 ± 122.8	0.37
SVR, dyn/s/sm⁻⁵	1252.7 ± 419.2	1213.0 ± 455.6	1018.0 ± 240.2	1576.5 ± 328.9	0.19

PH—pulmonary hypertension; PADN—pulmonary artery denervation; HR—heart rate; SBP—systolic blood pressure; DBP—diastolic blood pressure; mBP—mean arterial pressure; SPAP—systolic pulmonary arterial pressure; DPAP—diastolic pulmonary arterial pressure; mPAP—mean pulmonary artery pressure; RAP—right atrial pressure; PCWP—pulmonary capillary wedge pressure; CO—cardiac output; PVR—pulmonary vascular resistance; SVR—systemic vascular resistance

ISSN: 1471-2466