Parameters | Group I (PH-PADN), n = 6 | Group III (PH-shamPADN), n = 4 | p value* | Difference between PH 1 and PH 2 modeling | P value† | |
---|---|---|---|---|---|---|
Group I (PH-PADN), n = 6 | Group III (PH-shamPADN), n = 4 | |||||
Weight, kg | 35.7 ± 2.6 | 39.2 ± 1.9 | 0.038 | |||
TXA2 dose, μg/kg for PH 1 | 20.1 ± 7.1 | 24.5 ± 5.7 | 0.35 | 3.25 ± 1.9 | 3.26 ± 8.3 | 0.5 |
TXA2 dose, μg/kg for PH 2 | 18.9 ± 6.7 | 21.2 ± 8.2 | 0.9 | |||
Time to target mPAP-1, min | 20.0 ± 11.0 | 18.8 ± 6.3 | 0.76 | 4 ± 2.2 | 2.5 ± 10.4 | 0.73 |
Time to target mPAP-2, min | 18.3 ± 8.8 | 16.3 ± 9.5 | 0.61 | |||
HR, beat/min | 117.6 ± 20.6 | 115.8 ± 14.9 | 0.9 | 2.2 ± 10.6 | −5.5 ± 16.5 | 0.5 |
SBP, mmHg | 94.8 ± 13.8 | 104.0 ± 36.5 | 0.5 | 10.0 ± 10.9 | −1.0 ± 37.7 | 0.5 |
DBP, mmHg | 66.8 ± 12.5 | 62.3 ± 24.3 | 0.9 | 6.0 ± 6.5 | −0.8 ± 27.0 | 0.7 |
mBP, mm Hg | 76.2 ± 11.5 | 76.0 ± 27.9 | 0.9 | 7.2 ± 8.1 | −0.5 ± 30.0 | 0.7 |
SPAP, mm Hg | 44.6 ± 5.0 | 42.8 ± 1.0 | 0.28 | 1.2 ± 4.3 | −1.5 ± 3.1 | 0.28 |
DPAP, mm Hg | 34.4 ± 2.9 | 38.0 ± 0.8 | 0.06 | −1.2 ± 1.8 | −1.0 ± 1.4 | 0.9 |
mPAP, mm Hg | 38.2 ± 2.5 | 39.8 ± 0.5 | 0.5 | 0.0 ± 1.2 | −1.5 ± 1.7 | 0.2 |
mRAP, mm Hg | 7.2 ± 1.9 | 5.3 ± 2.2 | 0.28 | −2.2 ± 1.6 | 1.0 ± 0.8 | 0.015 |
PCWP, mm Hg | 5.6 ± 0.6 | 6.8 ± 10 | 0.11 | −1.2 ± 0.4 | 0.3 ± 1.3 | 0.06 |
CO, l/min | 3.0 ± 1.5 | 2.4 ± 0.7 | 1 | 0.8 ± 1.5 | 0.3 ± 1.4 | 0.9 |
PVR, dyn/s/sm−5 | 740.9 ± 421.2 | 1228.9 ± 524.3 | 0.4 | −171.6 ± 874.5 | 107.7 ± 798.2 | 0.9 |
SVR, dyn/s/sm−5 | 2091.8 ± 800.8 | 2373.7 ± 692.8 | 0.7 | 10.0 ± 623.1 | 101.0 ± 549.0 | 0.9 |