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Table 3 Hemodynamic data and the TXA2 dosage on PH modeling-2 in group I (PH-PADN) and group III (PH-shamPADN) (mean ± SD)

From: Transcatheter radiofrequency pulmonary artery denervation in swine: the evaluation of lesion degree, hemodynamics and pulmonary hypertension inducibility

Parameters

Group I (PH-PADN), n = 6

Group III (PH-shamPADN), n = 4

p value*

Difference between PH 1 and PH 2 modeling

P value

Group I (PH-PADN), n = 6

Group III (PH-shamPADN), n = 4

Weight, kg

35.7 ± 2.6

39.2 ± 1.9

0.038

   

TXA2 dose, μg/kg for PH 1

20.1 ± 7.1

24.5 ± 5.7

0.35

3.25 ± 1.9

3.26 ± 8.3

0.5

TXA2 dose, μg/kg for PH 2

18.9 ± 6.7

21.2 ± 8.2

0.9

Time to target mPAP-1, min

20.0 ± 11.0

18.8 ± 6.3

0.76

4 ± 2.2

2.5 ± 10.4

0.73

Time to target mPAP-2, min

18.3 ± 8.8

16.3 ± 9.5

0.61

HR, beat/min

117.6 ± 20.6

115.8 ± 14.9

0.9

2.2 ± 10.6

−5.5 ± 16.5

0.5

SBP, mmHg

94.8 ± 13.8

104.0 ± 36.5

0.5

10.0 ± 10.9

−1.0 ± 37.7

0.5

DBP, mmHg

66.8 ± 12.5

62.3 ± 24.3

0.9

6.0 ± 6.5

−0.8 ± 27.0

0.7

mBP, mm Hg

76.2 ± 11.5

76.0 ± 27.9

0.9

7.2 ± 8.1

−0.5 ± 30.0

0.7

SPAP, mm Hg

44.6 ± 5.0

42.8 ± 1.0

0.28

1.2 ± 4.3

−1.5 ± 3.1

0.28

DPAP, mm Hg

34.4 ± 2.9

38.0 ± 0.8

0.06

−1.2 ± 1.8

−1.0 ± 1.4

0.9

mPAP, mm Hg

38.2 ± 2.5

39.8 ± 0.5

0.5

0.0 ± 1.2

−1.5 ± 1.7

0.2

mRAP, mm Hg

7.2 ± 1.9

5.3 ± 2.2

0.28

−2.2 ± 1.6

1.0 ± 0.8

0.015

PCWP, mm Hg

5.6 ± 0.6

6.8 ± 10

0.11

−1.2 ± 0.4

0.3 ± 1.3

0.06

CO, l/min

3.0 ± 1.5

2.4 ± 0.7

1

0.8 ± 1.5

0.3 ± 1.4

0.9

PVR, dyn/s/sm−5

740.9 ± 421.2

1228.9 ± 524.3

0.4

−171.6 ± 874.5

107.7 ± 798.2

0.9

SVR, dyn/s/sm−5

2091.8 ± 800.8

2373.7 ± 692.8

0.7

10.0 ± 623.1

101.0 ± 549.0

0.9

  1. PH—pulmonary hypertension; PADN—pulmonary artery denervation; HR—heart rate; SBP—systolic blood pressure; DBP—diastolic blood pressure; mBP—mean arterial pressure; SPAP –systolic pulmonary arterial pressure; DPAP—diastolic pulmonary arterial pressure; mPAP—mean pulmonary artery pressure; RAP—right atrial pressure; PCWP—pulmonary capillary wedge pressure; CO—cardiac output; PVR—pulmonary vascular resistance; SVR—systemic vascular resistance
  2. *Mann–Whitney U two-sided exact test
  3. Wilcoxon signed-rank test