Table 1 Demographics and clinical characteristics of patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis at diagnosis
Characteristics | IPF (n = 259) | cHP (n = 152) | P |
|---|---|---|---|
Age, years | 66.7 (8.4) | 51.0 (13.3) | < 0.001 |
Male gender | 181 (69.9) | 76 (50.0) | < 0.001 |
Smoking status | |||
Non-smoker | 78 (30.1) | 103 (67.8) | < 0.001 |
Current or former smoker | 181 (69.9) | 49 (32.2) | |
BMI, kg/m2 | 28.3 (3.8) | 27.3 (4.9) | 0.024 |
Comorbidities | |||
Arterial hypertension | 159 (61.4) | 91 (59.9) | 0.834 |
Coronary artery disease | 79 (30.5) | 14 (9.2) | < 0.001 |
Diabetes mellitus | 62 (23.9) | 23 (15.1) | 0.043 |
Congestive heart failure | 47 (18.1) | 15 (9.9) | 0.032 |
Atrial fibrillation | 10 (3.9) | 1 (0.7) | 0.061 |
Pulmonary hypertension (by echocardiography) | 97 (48.5) | 44 (33.6) | 0.009 |
GERD | 43 (16.6) | 12 (7.9) | 0.016 |
Emphysema | 77 (29.8) | 23 (16.2) | 0.003 |
Stroke | 7 (2.7) | 3 (2.0) | 0.751 |
OSA | 6 (2.3) | 3 (2.0) | 1.000 |
Treatment | |||
ASA | 88 (34.1) | 19 (12.6) | < 0.001 |
Systemic steroid | 58 (22.4) | 137 (90.1) | < 0.001 |
Immunosuppressants | 34 (13.1) | 51 (33.6) | < 0.001 |
Pulmonary function test, % predicted | |||
FVC | 87.3 (20.0) | 80.9 (22.2) | 0.003 |
FEV1 | 89.5 (20.4) | 75.8 (20.7) | < 0.001 |
TLC | 81.9 (16.6) | 86.7 (22.2) | 0.013 |
DLco | 52.6 (16.8) | 51.2 (18.4) | 0.430 |
6-min walking distance (m) | 424.5 (123.0) | 481.6 (114.4) | < 0.001 |
D-dimer (µg/ml) | 935.5 (2078.6) | 516.6 (574.2) | 0.027 |
TVPG mmHg | 35.1 (12.5) | 30.2 (9.7) | < 0.001 |
CT angiogram performed | 64 (24.7) | 37 (24.3) | 1.000 |
Follow-up time, years | 3.9 (3.3) | 4.6 (3.5) | 0.042 |